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Role of Artificial Intelligence in Radiogenomics for Cancers in the Era of Precision Medicine

Overview
Journal Cancers (Basel)
Publisher MDPI
Specialty Oncology
Date 2022 Jun 24
PMID 35740526
Authors
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Abstract

Radiogenomics, a combination of "Radiomics" and "Genomics," using Artificial Intelligence (AI) has recently emerged as the state-of-the-art science in precision medicine, especially in oncology care. Radiogenomics syndicates large-scale quantifiable data extracted from radiological medical images enveloped with personalized genomic phenotypes. It fabricates a prediction model through various AI methods to stratify the risk of patients, monitor therapeutic approaches, and assess clinical outcomes. It has recently shown tremendous achievements in prognosis, treatment planning, survival prediction, heterogeneity analysis, reoccurrence, and progression-free survival for human cancer study. Although AI has shown immense performance in oncology care in various clinical aspects, it has several challenges and limitations. The proposed review provides an overview of radiogenomics with the viewpoints on the role of AI in terms of its promises for computational as well as oncological aspects and offers achievements and opportunities in the era of precision medicine. The review also presents various recommendations to diminish these obstacles.

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References
1.
Pareek G, Rajendra Acharya U, Sree S, Swapna G, Yantri R, Martis R . Prostate tissue characterization/classification in 144 patient population using wavelet and higher order spectra features from transrectal ultrasound images. Technol Cancer Res Treat. 2013; 12(6):545-57. DOI: 10.7785/tcrt.2012.500346. View

2.
Mazurowski M . Radiogenomics: what it is and why it is important. J Am Coll Radiol. 2015; 12(8):862-6. DOI: 10.1016/j.jacr.2015.04.019. View

3.
Vargas H, Huang E, Lakhman Y, Ippolito J, Bhosale P, Mellnick V . Radiogenomics of High-Grade Serous Ovarian Cancer: Multireader Multi-Institutional Study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group. Radiology. 2017; 285(2):482-492. PMC: 5673051. DOI: 10.1148/radiol.2017161870. View

4.
Pinker K, Chin J, Melsaether A, Morris E, Moy L . Precision Medicine and Radiogenomics in Breast Cancer: New Approaches toward Diagnosis and Treatment. Radiology. 2018; 287(3):732-747. DOI: 10.1148/radiol.2018172171. View

5.
Hsieh K, Chen C, Lo C . Radiomic model for predicting mutations in the isocitrate dehydrogenase gene in glioblastomas. Oncotarget. 2017; 8(28):45888-45897. PMC: 5542235. DOI: 10.18632/oncotarget.17585. View