Anti-Inflammatory and Anti-Acne Effects of Bark in Human Keratinocytes

Overview

Journal Antioxidants (Basel)

Date 2022 Jun 24

PMID 35740016

Authors

Stefano Piazza

Giulia Martinelli

Urska Vrhovsek

Domenico Masuero

Marco Fumagalli

Andrea Magnavacca

Carola Pozzoli

Luisa Canilli

Massimo Terno

Marco Angarano

Mario DellAgli

Enrico Sangiovanni

Affiliations

Soon will be listed here.

Abstract

() is recognized as one of the main triggers of the cutaneous inflammatory response in acne vulgaris, a chronic skin disorder with a multifactorial origin. Witch hazel ( L.) is a plant widely used for skin inflammatory conditions, with some preliminary anti-inflammatory evidence on the skin, but lacking data on acne conditions. This study aimed to evaluate the effect of a glycolic extract from bark (HVE) versus -induced inflammation in human keratinocytes (HaCaT). Phytochemical investigations of HVE identified hamamelitannin (HT) and proanthocyanidins as the most abundant compounds (respectively, 0.29% and 0.30% /). HVE inhibited -induced IL-6 release (IC: 136.90 μg/mL), by partially impairing NF-κB activation; however, no antibacterial or antibiofilm activities were found. In addition, HVE showed greater anti-inflammatory activity when TNF-α was used as a proinflammatory stimulus (IC of 38.93 μg/mL for IL-8 release), partially acting by antioxidant mechanisms, as shown for VEGF inhibition. The effects of HVE are primarily based on the proanthocyanidin content, as HT was found inactive on all the parameters tested. These results suggest further investigations of HVE in other inflammatory-based skin diseases.

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