The Multiple Effects of Vitamin D Against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

Overview

Journal Antioxidants (Basel)

Date 2022 Jun 24

PMID 35739987

Authors

Massimiliano Berretta

Vincenzo Quagliariello

Alessia Bignucolo

Sergio Facchini

Nicola Maurea

Raffaele di Francia

Francesco Fiorica

Saman Sharifi

Silvia Bressan

Sara N Richter

Valentina Camozzi

Luca Rinaldi

Carla Scaroni

Monica Montopoli

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent.

Methods: A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health.

Results: In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases.

Conclusions: Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.

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