Regional Years of Life Lost, Years Lived with Disability, and Disability-adjusted Life-years for Severe Mental Disorders in Guangdong Province, China: a Real-world Longitudinal Study

Overview

Journal Glob Health Res Policy

Publisher Biomed Central

Specialty Public Health

Date 2022 Jun 20

PMID 35725574

Authors

Wenyan Tan

Lichang Chen

Yuqin Zhang

Junyan Xi

Yuantao Hao

Fujun Jia

Brian J Hall

Jing Gu

Shibin Wang

Haicheng Lin

Xiao Lin

Affiliations

Soon will be listed here.

Abstract

Background: To understand the magnitude and spatial-temporal distribution of the regional burden attributable to severe mental disorders is of great essential and high policy relevance. The study aimed to address the burden of severe mental disorders by evaluating the years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) in Guangdong, China.

Methods: We undertook a longitudinal study based on a multicenter database established by the Health Commission of Guangdong, involving a total of 21 prefectures and four economic regions in the Guangdong province. A total of 520,731 medical records from patients with severe mental disorders were collected for 2010-2020. Data were analyzed via an integrated evaluation framework by synthesizing prevalence estimates, epidemiological adjustment as well as comorbidity assessment to develop internally consistent estimates of DALY. DALY changes during 2010-2020 were decomposed by population growth and aging and further grouped by Socio-demographic Index (SDI). DALYs were projected to 2030 by the weighted median annualized rate of change in 2010-2020.

Results: In 2010-2020, the average DALYs for severe mental disorders reached 798,474 (95% uncertainty interval [UI]: 536,280-1,270,465) person-years (52.2% for males, and 47.8% for females). Severe mental disorders led to a great amount of disease burden, especially in Guangzhou, Shenzhen, and Foshan cities. Schizophrenia and mental retardation with mental disorders were the two leading sources of the burden ascribed to severe mental disorders. Population growth and aging could be accountable for the increasing burden of severe mental disorders. Economic regions with higher SDI carried a greater burden but had lower annualized rates of change in DALYs. The overall burden of severe mental disorders is projected to rise modestly over the next decade.

Conclusions: The findings urge prioritization of initiatives focused on public mental health, prevention strategies, health resources reallocation, and active involvement of authorities to effectively address the anticipated needs.

Citing Articles

Temporal and geographical dynamics of early-onset Parkinson's disease burden: insights from the Global Burden of Disease Study 2021.

Li Y, Tan D, Luo C, Chen J Front Neurol. 2025; 16:1473548.

PMID: 39949791 PMC: 11821659. DOI: 10.3389/fneur.2025.1473548.

Chinese burden of depressive disorders from 1990 to 2021 and prediction for 2030: analysis of data from the global burden of disease study 2021.

Yan N, Zhang C, Wang Y, Wang Y, Luo Y, Wang Y BMC Psychol. 2025; 13(1):30.

PMID: 39794816 PMC: 11720356. DOI: 10.1186/s40359-025-02349-0.

An Application of : A Spiritual, Cost-Effective, Indigenous Low-Intensity Psychological Intervention to Manage Common Mental Disorders: A Cross-Sectional Pilot Study in India.

Balkrishna A, Gupta A, Ghosh S, Arya V J Evid Based Integr Med. 2024; 29:2515690X241284280.

PMID: 39403733 PMC: 11526240. DOI: 10.1177/2515690X241284280.

Association Between Extreme Heat and Outpatient Visits for Mental Disorders: A Time-Series Analysis in Guangzhou, China.

Zhang H, Li X, Wang S, Wu T, Yang X, Wang N Geohealth. 2024; 8(10):e2024GH001165.

PMID: 39355273 PMC: 11442485. DOI: 10.1029/2024GH001165.

Association between elevated serum matrix metalloproteinase-2 and tumor necrosis factor-α, and clinical symptoms in male patients with treatment-resistant and chronic medicated schizophrenia.

Yang H, Peng R, Yang M, Zhang J, Shi Z, Zhang X BMC Psychiatry. 2024; 24(1):173.

PMID: 38429778 PMC: 10905811. DOI: 10.1186/s12888-024-05621-6.

References

Bonadiman C, Malta D, Passos V, Naghavi M, Melo A . Depressive disorders in Brazil: results from the Global Burden of Disease Study 2017. Popul Health Metr. 2020; 18(Suppl 1):6. PMC: 7526360. DOI: 10.1186/s12963-020-00204-5. View

Huang Y, Wang Y, Wang H, Liu Z, Yu X, Yan J . Prevalence of mental disorders in China: a cross-sectional epidemiological study. Lancet Psychiatry. 2019; 6(3):211-224. DOI: 10.1016/S2215-0366(18)30511-X. View

Fernandez de Larrea-Baz N, Alvarez-Martin E, Morant-Ginestar C, Genova-Maleras R, Gil A, Perez-Gomez B . Burden of disease due to cancer in Spain. BMC Public Health. 2009; 9:42. PMC: 2642814. DOI: 10.1186/1471-2458-9-42. View

Liang D, Mays V, Hwang W . Integrated mental health services in China: challenges and planning for the future. Health Policy Plan. 2017; 33(1):107-122. PMC: 5886187. DOI: 10.1093/heapol/czx137. View

Hu X, Rohrbaugh R, Deng Q, He Q, Munger K, Liu Z . Expanding the Mental Health Workforce in China: Narrowing the Mental Health Service Gap. Psychiatr Serv. 2017; 68(10):987-989. DOI: 10.1176/appi.ps.201700002. View

. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. Lancet. 2017; 390(10100):1423-1459. PMC: 5603800. DOI: 10.1016/S0140-6736(17)32336-X. View

Tian M, Feng D, Chen X, Chen Y, Sun X, Xiang Y . China's rural public health system performance: a cross-sectional study. PLoS One. 2014; 8(12):e83822. PMC: 3873379. DOI: 10.1371/journal.pone.0083822. View

Davis J, Eyre H, Jacka F, Dodd S, Dean O, McEwen S . A review of vulnerability and risks for schizophrenia: Beyond the two hit hypothesis. Neurosci Biobehav Rev. 2016; 65:185-94. PMC: 4876729. DOI: 10.1016/j.neubiorev.2016.03.017. View

. Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1813-1850. PMC: 5055583. DOI: 10.1016/S0140-6736(16)31467-2. View

10.

Bemme D, Dsouza N . Global mental health and its discontents: an inquiry into the making of global and local scale. Transcult Psychiatry. 2014; 51(6):850-74. DOI: 10.1177/1363461514539830. View

11.

Herrman H, Jane-Llopis E . Mental health promotion in public health. Promot Educ. 2005; Suppl 2:42-7, 63, 69. DOI: 10.1177/10253823050120020107. View

12.

Tan W, Lin H, Lei B, Ou A, He Z, Yang N . The psychosis analysis in real-world on a cohort of large-scale patients with schizophrenia. BMC Med Inform Decis Mak. 2020; 20(Suppl 3):132. PMC: 7477870. DOI: 10.1186/s12911-020-1125-0. View

13.

Naber D, Hansen K, Forray C, Baker R, Sapin C, Beillat M . Qualify: a randomized head-to-head study of aripiprazole once-monthly and paliperidone palmitate in the treatment of schizophrenia. Schizophr Res. 2015; 168(1-2):498-504. DOI: 10.1016/j.schres.2015.07.007. View

14.

Yang G, Wang Y, Zeng Y, Gao G, Liang X, Zhou M . Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2013; 381(9882):1987-2015. PMC: 7159289. DOI: 10.1016/S0140-6736(13)61097-1. View

15.

van Hoeken D, Hoek H . Review of the burden of eating disorders: mortality, disability, costs, quality of life, and family burden. Curr Opin Psychiatry. 2020; 33(6):521-527. PMC: 7575017. DOI: 10.1097/YCO.0000000000000641. View

16.

Tsai A . Syndemics: A theory in search of data or data in search of a theory?. Soc Sci Med. 2018; 206:117-122. PMC: 6613368. DOI: 10.1016/j.socscimed.2018.03.040. View

17.

Devleesschauwer B, Haagsma J, Angulo F, Bellinger D, Cole D, Dopfer D . Methodological Framework for World Health Organization Estimates of the Global Burden of Foodborne Disease. PLoS One. 2015; 10(12):e0142498. PMC: 4668830. DOI: 10.1371/journal.pone.0142498. View

18.

Fan V, Mahadevan R, Leung J . Effect of income inequality, community infrastructure and individual stressors on adult depression. Health Promot Int. 2020; 36(1):46-57. DOI: 10.1093/heapro/daaa036. View

19.

Andrews G, Henderson S, Hall W . Prevalence, comorbidity, disability and service utilisation. Overview of the Australian National Mental Health Survey. Br J Psychiatry. 2001; 178:145-53. DOI: 10.1192/bjp.178.2.145. View

20.

Demyttenaere K, Bruffaerts R, Posada-Villa J, Gasquet I, Kovess V, Lepine J . Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. JAMA. 2004; 291(21):2581-90. DOI: 10.1001/jama.291.21.2581. View