Serum Vitamin D Insufficiency in Hospitalized Full-Term Neonates at a Tertiary Hospital in Eastern China

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2022 Jun 20

PMID 35722480

Authors

Huawei Wang

Yiming Du

Zhixin Wu

Haifeng Geng

Xueping Zhu

Xiaoli Zhu

Affiliations

Soon will be listed here.

Abstract

Objective: This study explored the status of serum vitamin D in hospitalized full-term neonates at a tertiary hospital in eastern China.

Methods: A prospective study was conducted among 471 hospitalized full-term neonates at the Children's Hospital of Soochow University between January 1 and June 20, 2020. Perinatal clinical data, serum 25-hydroxyvitamin D (25(OH)D), laboratory examinations, serum calcium levels, and immune function were obtained and analyzed. We explored and analyzed the risk factors for vitamin D insufficiency or deficiency, and we also attempted to determine correlations between vitamin D and its influence on immunity.

Results: The mean serum 25(OH)D was 33.65±6.07ng/ml.The prevalence of vitamin D insufficiency was 28.24%,vitamin D sufficiency was 71.76%, there was no vitamin D deficiency. The serum 25-(OH)D in singleton neonate was higher than twins or multiple infants ( = -10.918, = 0.000). The serum 25-(OH)D were higher in neonates who born in spring and summer than in winter (H = 13.443, = 0.001). The serum 25-(OH)D in appropriate for gestational age (AGA) and large for gestational age (LGA) neonates were higher than small for gestational age (SGA) (H = 7.686, = 0.021). The serum 25-(OH)D were higher in neonates whose mothers had no underlying diseases than those with certain immunological and infectious diseases (F = 12.417, = 0.000). The serum 25-(OH)D in neonates whose mothers had none or one perinatal complication were higher than those with two or more (F = 13.299, = 0.000). The neonates with eosinophils ≤5% or normal platelet counts or serum Ca ≥0.9 mmol/L have higher serum 25-(OH)D. Neonates born in winter were at risk for vitamin D insufficiency, and the incidence of infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia in the vitamin D insufficiency group were higher than sufficiency group ( < 0.05). The serum CD3+, CD3+CD4+, and IgA levels in vitamin D sufficiency neonates were significantly higher than those in insufficiency group ( < 0.05).

Conclusion: The prevalence of vitamin D insufficiency was 28.24%, and birth in winter was a risk factor for vitamin D insufficiency in hospitalized full-term neonates in Suzhou area. Neonates with infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia exhibited a high risk of vitamin D insufficiency. The serum CD3, CD3CD4, and IgA levels in neonates with vitamin D insufficiency were lower.

Citing Articles

Immune Modulatory Effects of Vitamin D on Herpesvirus Infections.

Galdo-Torres D, Andreu S, Caballero O, Hernandez-Ruiz I, Ripa I, Bello-Morales R Int J Mol Sci. 2025; 26(4).

PMID: 40004230 PMC: 11855552. DOI: 10.3390/ijms26041767.

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