Modifying Beauty Is Not Priceless: A Rare Case of Silicone-Induced Hypercalcemia With Renal Failure

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Jun 20

PMID 35720781

Authors

Nusha Fareen

Mohammad Umair Zafar

Zaka Ahmed

Mohammad A Hossain

Sushmitha P Diraviam

Sobaan Taj

Avais Masud

Affiliations

Soon will be listed here.

Abstract

Silicone implant-induced hypercalcemia is a rather rare pathological entity. There are only a few published reports on the topic. Here, we have reported a case of acute kidney injury in the background of hypercalcemia and elevated vitamin D level in a transgender patient with a history of silicone injections in the breast and buttocks for cosmetic purposes.

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References

Norena J, Nino C, Gallego S, Builes-Barrera C, Castro D, Roman-Gonzalez A . Calcitriol-mediated hypercalcemia secondary to granulomatous disease caused by soft-tissue filler injection: a case report. Clin Cases Miner Bone Metab. 2018; 14(3):340-346. PMC: 5762227. DOI: 10.11138/ccmbm/2017.14.3.340. View

Tanne J . FDA approves silicone breast implants 14 years after their withdrawal. BMJ. 2006; 333(7579):1139. PMC: 1676088. DOI: 10.1136/bmj.39048.332650.DB. View

Conron M, Young C, Beynon H . Calcium metabolism in sarcoidosis and its clinical implications. Rheumatology (Oxford). 2000; 39(7):707-13. DOI: 10.1093/rheumatology/39.7.707. View

Yedla N, Perez E, Lagari V, Ayala A . SILICONE GRANULOMATOUS INFLAMMATION RESULTING IN HYPERCALCEMIA: A REVIEW OF THE LITERATURE. AACE Clin Case Rep. 2020; 5(2):e119-e123. PMC: 6873861. DOI: 10.4158/ACCR-2018-0277. View

Saggese G, Bertelloni S, Baroncelli G, Di Nero G . Ketoconazole decreases the serum ionized calcium and 1,25-dihydroxyvitamin D levels in tuberculosis-associated hypercalcemia. Am J Dis Child. 1993; 147(3):270-3. DOI: 10.1001/archpedi.1993.02160270032013. View

Hamadeh M, Fares J, Maatouk K, Darwish M . Hypercalcemia in a bodybuilder with cosmetic silicone injections. N Z Med J. 2018; 131(1473):78-81. View

Watad A, Rosenberg V, Tiosano S, Cohen Tervaert J, Yavne Y, Shoenfeld Y . Silicone breast implants and the risk of autoimmune/rheumatic disorders: a real-world analysis. Int J Epidemiol. 2018; 47(6):1846-1854. DOI: 10.1093/ije/dyy217. View

Agrawal N, Altiner S, Mezitis N, Helbig S . Silicone-induced granuloma after injection for cosmetic purposes: a rare entity of calcitriol-mediated hypercalcemia. Case Rep Med. 2013; 2013:807292. PMC: 3864076. DOI: 10.1155/2013/807292. View

Kozeny G, Barbato A, Bansal V, Vertuno L, HANO J . Hypercalcemia associated with silicone-induced granulomas. N Engl J Med. 1984; 311(17):1103-5. DOI: 10.1056/NEJM198410253111707. View

10.

Edwards B, Saraykar S, Sun M, Murphy Jr W, Lin P, Gagel R . Resection of granulomatous tissue resolves silicone induced hypercalcemia. Bone Rep. 2017; 5:163-167. PMC: 5440967. DOI: 10.1016/j.bonr.2015.07.001. View

11.

Glass A, Eil C . Ketoconazole-induced reduction in serum 1,25-dihydroxyvitamin D and total serum calcium in hypercalcemic patients. J Clin Endocrinol Metab. 1988; 66(5):934-8. DOI: 10.1210/jcem-66-5-934. View

12.

Rodriguez I, Deleyiannis F . Hypercalcemia Secondary to Silicone Breast Implant Rupture: A Rare Entity to Keep in Mind. Plast Reconstr Surg Glob Open. 2017; 5(7):e1416. PMC: 5548579. DOI: 10.1097/GOX.0000000000001416. View

13.

Cheema C, Grant B, Marcus R . Effects of estrogen on circulating "free" and total 1,25-dihydroxyvitamin D and on the parathyroid-vitamin D axis in postmenopausal women. J Clin Invest. 1989; 83(2):537-42. PMC: 303712. DOI: 10.1172/JCI113915. View

14.

Man Singh Dangol G, Negrete H . Silicone-Induced Granulomatous Reaction Causing Severe Hypercalcemia: Case Report and Literature Review. Case Rep Nephrol. 2019; 2019:9126172. PMC: 6341244. DOI: 10.1155/2019/9126172. View

15.

WINER L, STERNBERG T, Lehman R, ASHLEY F . TISSUE REACTIONS TO INJECTED SILICONE LIQUIDS. A REPORT OF THREE CASES. Arch Dermatol. 1964; 90:588-93. DOI: 10.1001/archderm.1964.01600060054010. View

16.

Moraitis A, Hewison M, Collins M, Anaya C, Holick M . Hypercalcemia associated with mineral oil-induced sclerosing paraffinomas. Endocr Pract. 2013; 19(2):e50-6. DOI: 10.4158/EP12092.CR. View

17.

Schanz J, Flux K, Kircher C, Tsioga M, Hartschuh W, Nawroth P . Mirror, mirror on the wall: hypercalcemia as a consequence of modern cosmetic treatment with liquid silicone. Med Sci Monit. 2012; 18(2):CS5-7. PMC: 3560594. DOI: 10.12659/msm.882450. View