Non-Coding RNAs As Novel Regulators of Neuroinflammation in Alzheimer's Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Jun 20

PMID 35720333

Authors

Yuqing Liu

Xin Cheng

Hongli Li

Shan Hui

Zheyu Zhang

Yang Xiao

Weijun Peng

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is one of the most common causes of dementia. Although significant breakthroughs have been made in understanding the progression and pathogenesis of AD, it remains a worldwide problem and a significant public health burden. Thus, more efficient diagnostic and therapeutic strategies are urgently required. The latest research studies have revealed that neuroinflammation is crucial in the pathogenesis of AD. Non-coding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs), PIWI-interacting RNAs (piRNAs), and transfer RNA-derived small RNAs (tsRNAs), have been strongly associated with AD-induced neuroinflammation. Furthermore, several ongoing pre-clinical studies are currently investigating ncRNA as disease biomarkers and therapeutic interventions to provide new perspectives for AD diagnosis and treatment. In this review, the role of different types of ncRNAs in neuroinflammation during AD are summarized in order to improve our understanding of AD etiology and aid in the translation of basic research into clinical practice.

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References

Wang X, Liu D, Huang H, Wang Z, Hou T, Yang X . A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease. Biol Psychiatry. 2017; 83(5):395-405. DOI: 10.1016/j.biopsych.2017.07.023. View

Xu N, Li A, Ji L, Ye Y, Wang Z, Tong L . miR-132 regulates the expression of synaptic proteins in APP/PS1 transgenic mice through C1q. Eur J Histochem. 2019; 63(2). PMC: 6511887. DOI: 10.4081/ejh.2019.3008. View

Roush S, Slack F . The let-7 family of microRNAs. Trends Cell Biol. 2008; 18(10):505-16. DOI: 10.1016/j.tcb.2008.07.007. View

Hammond S, Aartsma-Rus A, Alves S, Borgos S, Buijsen R, Collin R . Delivery of oligonucleotide-based therapeutics: challenges and opportunities. EMBO Mol Med. 2021; 13(4):e13243. PMC: 8033518. DOI: 10.15252/emmm.202013243. View

Xu X, Zhang J, Tian Y, Gao Y, Dong X, Chen W . CircRNA inhibits DNA damage repair by interacting with host gene. Mol Cancer. 2020; 19(1):128. PMC: 7446195. DOI: 10.1186/s12943-020-01246-x. View

Min J, Lee J, Mun H, Kim D, Park B, Yoon B . Diagnostic and therapeutic biomarkers for Alzheimer's disease in human-derived platelets. Genes Genomics. 2020; 42(12):1467-1475. DOI: 10.1007/s13258-020-01015-6. View

Carthew R, Sontheimer E . Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009; 136(4):642-55. PMC: 2675692. DOI: 10.1016/j.cell.2009.01.035. View

Bhattacharjee S, Zhao Y, Dua P, Rogaev E, Lukiw W . microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. PLoS One. 2016; 11(3):e0150211. PMC: 4780721. DOI: 10.1371/journal.pone.0150211. View

Pulina M, Hopkins M, Haroutunian V, Greengard P, Bustos V . C99 selectively accumulates in vulnerable neurons in Alzheimer's disease. Alzheimers Dement. 2019; 16(2):273-282. DOI: 10.1016/j.jalz.2019.09.002. View

10.

Tatulian S . Challenges and hopes for Alzheimer's disease. Drug Discov Today. 2022; 27(4):1027-1043. DOI: 10.1016/j.drudis.2022.01.016. View

11.

Hadar A, Milanesi E, Walczak M, Puzianowska-Kuznicka M, Kuznicki J, Squassina A . SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Sci Rep. 2018; 8(1):8465. PMC: 5981646. DOI: 10.1038/s41598-018-26547-6. View

12.

Li Y, Wang R, Zhang S, Xu H, Deng L . LRGCPND: Predicting Associations between ncRNA and Drug Resistance via Linear Residual Graph Convolution. Int J Mol Sci. 2021; 22(19). PMC: 8508984. DOI: 10.3390/ijms221910508. View

13.

Li A, Tong L, Xu N, Ye Y, Nie P, Wang Z . miR-124 regulates cerebromicrovascular function in APP/PS1 transgenic mice via C1ql3. Brain Res Bull. 2019; 153:214-222. DOI: 10.1016/j.brainresbull.2019.09.002. View

14.

Ansari A, Maffioletti E, Milanesi E, Marizzoni M, Frisoni G, Blin O . miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer's disease. Neurobiol Aging. 2019; 82:102-109. DOI: 10.1016/j.neurobiolaging.2019.06.005. View

15.

Di Ianni T, Bose R, Sukumar U, Bachawal S, Wang H, Telichko A . Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs. J Control Release. 2019; 309:1-10. PMC: 6815710. DOI: 10.1016/j.jconrel.2019.07.024. View

16.

Cai Z, Qiao P, Wan C, Cai M, Zhou N, Li Q . Role of Blood-Brain Barrier in Alzheimer's Disease. J Alzheimers Dis. 2018; 63(4):1223-1234. DOI: 10.3233/JAD-180098. View

17.

Diepenbruck M, Tiede S, Saxena M, Ivanek R, Kalathur R, Luond F . miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis. Nat Commun. 2017; 8(1):1168. PMC: 5660124. DOI: 10.1038/s41467-017-01197-w. View

18.

van den Berg M, Krauskopf J, Ramaekers J, Kleinjans J, Prickaerts J, Briede J . Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders. Prog Neurobiol. 2019; 185:101732. DOI: 10.1016/j.pneurobio.2019.101732. View

19.

Haneklaus M, Gerlic M, ONeill L, Masters S . miR-223: infection, inflammation and cancer. J Intern Med. 2013; 274(3):215-26. PMC: 7166861. DOI: 10.1111/joim.12099. View

20.

Zhang N, Gao Y, Yu S, Sun X, Shen K . Berberine attenuates Aβ42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells. Life Sci. 2020; 252:117637. DOI: 10.1016/j.lfs.2020.117637. View