Extensively Drug-resistant (XDR) Causing Possible Gonorrhoea Treatment Failure with Ceftriaxone Plus Azithromycin in Austria, April 2022

Overview

Journal Euro Surveill

Specialty Infectious Diseases

Date 2022 Jun 17

PMID 35713023

Authors

Sonja Pleininger

Alexander Indra

Daniel Golparian

Florian Heger

Stefanie Schindler

Susanne Jacobsson

Stefan Heidler

Magnus Unemo

Affiliations

Soon will be listed here.

Abstract

We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia. Recommended treatment with ceftriaxone (1 g) plus azithromycin (1.5 g) possibly failed. Worryingly, this is the second strain in an Asian genomic sublineage including high-level azithromycin-resistant strains that developed ceftriaxone resistance by acquisition of mosaic -60.001. Enhanced resistance surveillance and actions are imperative to prevent spread.

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