Neuroprotection in Acute Ischemic Stroke: A Battle Against the Biology of Nature

Overview

Journal Front Neurol

Specialty Neurology

Date 2022 Jun 17

PMID 35711268

Authors

Sherief Ghozy

Abdullah Reda

Joseph Varney

Ahmed Sallam ElHawary

Jaffer Shah

Kimberly Murry

Mohamed Gomaa Sobeeh

Sandeep S Nayak

Ahmed Y Azzam

Waleed Brinjikji

Ramanathan Kadirvel

David F Kallmes

Affiliations

Soon will be listed here.

Abstract

Stroke is the second most common cause of global death following coronary artery disease. Time is crucial in managing stroke to reduce the rapidly progressing insult of the ischemic penumbra and the serious neurologic deficits that might follow it. Strokes are mainly either hemorrhagic or ischemic, with ischemic being the most common of all types of strokes. Thrombolytic therapy with recombinant tissue plasminogen activator and endovascular thrombectomy are the main types of management of acute ischemic stroke (AIS). In addition, there is a vital need for neuroprotection in the setting of AIS. Neuroprotective agents are important to investigate as they may reduce mortality, lessen disability, and improve quality of life after AIS. In our review, we will discuss the main types of management and the different modalities of neuroprotection, their mechanisms of action, and evidence of their effectiveness after ischemic stroke.

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