SFPQ Promotes Lung Cancer Malignancy Regulation of CD44 V6 Expression

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Jun 16

PMID 35707369

Authors

Libang Yang

Jianbo Yang

Blake Jacobson

Adam Gilbertsen

Karen Smith

LeeAnn Higgins

Candace Guerrero

Hong Xia

Craig A Henke

Jizhen Lin

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) contribute to tumor pathogenesis and elicit antitumor immune responses in tumor microenvironments. Nuclear proteins might be the main players in these processes. In the current study, combining spatial proteomics with ingenuity pathway analysis (IPA) in lung non-small cell (NSC) cancer MSCs, we identify a key nuclear protein regulator, SFPQ (Splicing Factor Proline and Glutamine Rich), which is overexpressed in lung cancer MSCs and functions to promote MSCs proliferation, chemical resistance, and invasion. Mechanistically, the knockdown of SFPQ reduces CD44v6 expression to inhibit lung cancer MSCs stemness, proliferation , and metastasis . The data indicates that SFPQ may be a potential therapeutic target for limiting growth, chemotherapy resistance, and metastasis of lung cancer.

Citing Articles

Spatial proteomics: unveiling the multidimensional landscape of protein localization in human diseases.

Wu M, Tao H, Xu T, Zheng X, Wen C, Wang G Proteome Sci. 2024; 22(1):7.

PMID: 39304896 PMC: 11416001. DOI: 10.1186/s12953-024-00231-2.

Serum Splicing Factor Proline- and Glutamine-Rich Is a Diagnostic Marker for Non-Small-Cell Lung Cancer and Other Solid Cancers.

Yang L, Gilbertsen A, Jacobson B, Kratzke R, Henke C Int J Mol Sci. 2024; 25(16).

PMID: 39201453 PMC: 11354699. DOI: 10.3390/ijms25168766.

RNA-binding proteins regulating the CD44 alternative splicing.

Maltseva D, Tonevitsky A Front Mol Biosci. 2023; 10:1326148.

PMID: 38106992 PMC: 10722200. DOI: 10.3389/fmolb.2023.1326148.

CD44v6, STn & O-GD2: promising tumor associated antigens paving the way for new targeted cancer therapies.

Lodewijk I, Duenas M, Paramio J, Rubio C Front Immunol. 2023; 14:1272681.

PMID: 37854601 PMC: 10579806. DOI: 10.3389/fimmu.2023.1272681.

SFPQ and Its Isoform as Potential Biomarker for Non-Small-Cell Lung Cancer.

Yang L, Gilbertsen A, Jacobson B, Pham J, Fujioka N, Henke C Int J Mol Sci. 2023; 24(15).

PMID: 37569873 PMC: 10419845. DOI: 10.3390/ijms241512500.

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