A 2D Nanotheranostic Platform Based on Graphene Oxide and Phase-change Materials for Bimodal CT/MR Imaging, NIR-activated Drug Release, and Synergistic Thermo-chemotherapy

Overview

Journal Nanotheranostics

Specialty Biotechnology

Date 2022 Jun 16

PMID 35707061

Authors

Mehri Mirrahimi

Zahra Alamzadeh

Jaber Beik

Abolfazl Sarikhani

Mahdie Mousavi

Rasoul Irajirad

Tahereh Khani

Elnaz S Davani

Ali Farashahi

Tahereh Shakerian Ardakani

Jeff W M Bulte

Habib Ghaznavi

Ali Shakeri-Zadeh

Affiliations

Soon will be listed here.

Abstract

Recent years have seen considerable progress in the development of nanomedicine by the advent of 2D nanomaterials serving as ideal platforms to integrate multiple theranostic functions. We synthesized multifunctional stimuli-responsive 2D-based smart nanocomposites (NCs), comprising gold nanoparticles (AuNPs) and superparamagnetic iron oxides (SPIOs) scaffolded within graphene oxide (GO) nanosheets, coated with doxorubicin (DOX)-loaded 1-tetradecanol (TD), and further modified with an alginate (Alg) polymer. TD is a phase-change material (PCM) that confines DOX molecules to the GO surface and melts when the temperature exceeds its melting point (m=39 °C), causing the PCM to release its drug payload. By virtue of their strong near-infrared (NIR) light absorption and high photothermal conversion efficiency, GO nanosheets may enable photothermal therapy (PTT) and activate a phase change to trigger DOX release. Upon NIR irradiation of NCs, a synergistic thermo-chemotherapeutic effect can be obtained by GO-mediated PTT, resulting an accelerated and controllable drug release through the PCM mechanism. The biodistribution of these NCs could also be imaged with computed tomography (CT) and magnetic resonance (MR) imaging in vitro and in vivo. Hence, this multifunctional nanotheranostic platform based on 2D nanomaterials appears a promising candidate for multimodal image-guided cancer therapy.

Citing Articles

Advances in Nanotheranostic Systems for Concurrent Cancer Imaging and Therapy: An Overview of the Last 5 Years.

Lankoff A, Czerwinska M, Kruszewski M Molecules. 2025; 29(24.

PMID: 39770074 PMC: 11677634. DOI: 10.3390/molecules29245985.

Nano-drug delivery system targeting FAP for the combined treatment of oral leukoplakia.

Li R, Zhao Y, Liu T, Li Y, Wan C, Gao R Drug Deliv Transl Res. 2023; 14(1):247-265.

PMID: 37526880 DOI: 10.1007/s13346-023-01397-6.

A Targeted and pH-Responsive Nano-Graphene Oxide Nanoparticle Loaded with Doxorubicin for Synergetic Chemo-Photothermal Therapy of Oral Squamous Cell Carcinoma.

Li R, Liu C, Wan C, Liu T, Zhang R, Du J Int J Nanomedicine. 2023; 18:3309-3324.

PMID: 37351329 PMC: 10284161. DOI: 10.2147/IJN.S402249.

Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities.

Kashyap B, Singh V, Solanki M, Kumar A, Ruokolainen J, Kesari K ACS Omega. 2023; 8(16):14290-14320.

PMID: 37125102 PMC: 10134471. DOI: 10.1021/acsomega.2c07840.

Nanomaterial-Based Antivascular Therapy in the Multimodal Treatment of Cancer.

Ma X, Fang W, Wang D, Shao N, Chen J, Nie T Pharmaceutics. 2023; 15(4).

PMID: 37111692 PMC: 10145863. DOI: 10.3390/pharmaceutics15041207.

References

Fan W, Yung B, Huang P, Chen X . Nanotechnology for Multimodal Synergistic Cancer Therapy. Chem Rev. 2017; 117(22):13566-13638. DOI: 10.1021/acs.chemrev.7b00258. View

Tian G, Zhang X, Gu Z, Zhao Y . Recent Advances in Upconversion Nanoparticles-Based Multifunctional Nanocomposites for Combined Cancer Therapy. Adv Mater. 2015; 27(47):7692-712. DOI: 10.1002/adma.201503280. View

Shakeri-Zadeh A, Khoei S, Khoee S, Sharifi A, Shiran M . Combination of ultrasound and newly synthesized magnetic nanocapsules affects the temperature profile of CT26 tumors in BALB/c mice. J Med Ultrason (2001). 2015; 42(1):9-16. DOI: 10.1007/s10396-014-0558-4. View

Khademi S, Sarkar S, Shakeri-Zadeh A, Attaran N, Kharrazi S, Ay M . Targeted gold nanoparticles enable molecular CT imaging of head and neck cancer: An in vivo study. Int J Biochem Cell Biol. 2019; 114:105554. DOI: 10.1016/j.biocel.2019.06.002. View

Khani T, Alamzadeh Z, Sarikhani A, Mousavi M, Mirrahimi M, Tabei M . FeO@Au core-shell hybrid nanocomposite for MRI-guided magnetic targeted photo-chemotherapy. Lasers Med Sci. 2022; 37(5):2387-2395. DOI: 10.1007/s10103-021-03486-9. View

Yang K, Feng L, Liu Z . Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy. Adv Drug Deliv Rev. 2016; 105(Pt B):228-241. DOI: 10.1016/j.addr.2016.05.015. View

Fraga S, Brandao A, Soares M, Morais T, Duarte J, Pereira L . Short- and long-term distribution and toxicity of gold nanoparticles in the rat after a single-dose intravenous administration. Nanomedicine. 2014; 10(8):1757-66. DOI: 10.1016/j.nano.2014.06.005. View

Mirrahimi M, Khateri M, Beik J, Ghoreishi F, Shiralizadeh Dezfuli A, Ghaznavi H . Enhancement of chemoradiation by co-incorporation of gold nanoparticles and cisplatin into alginate hydrogel. J Biomed Mater Res B Appl Biomater. 2019; 107(8):2658-2663. DOI: 10.1002/jbm.b.34356. View

Rodrigues R, Baldi G, Doumett S, Garcia-Hevia L, Gallo J, Banobre-Lopez M . Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery. Mater Sci Eng C Mater Biol Appl. 2018; 93:206-217. DOI: 10.1016/j.msec.2018.07.060. View

10.

Movahedi M, Mehdizadeh A, Koosha F, Eslahi N, Pirhajati Mahabadi V, Ghaznavi H . Investigating the photo-thermo-radiosensitization effects of folate-conjugated gold nanorods on KB nasopharyngeal carcinoma cells. Photodiagnosis Photodyn Ther. 2018; 24:324-331. DOI: 10.1016/j.pdpdt.2018.10.016. View

11.

Guo Y, Zhang Y, Ma J, Li Q, Li Y, Zhou X . Light/magnetic hyperthermia triggered drug released from multi-functional thermo-sensitive magnetoliposomes for precise cancer synergetic theranostics. J Control Release. 2017; 272:145-158. DOI: 10.1016/j.jconrel.2017.04.028. View

12.

Alamzadeh Z, Beik J, Pirhajati Mahabadi V, Abbasian Ardekani A, Ghader A, Kamrava S . Ultrastructural and optical characteristics of cancer cells treated by a nanotechnology based chemo-photothermal therapy method. J Photochem Photobiol B. 2019; 192:19-25. DOI: 10.1016/j.jphotobiol.2019.01.005. View

13.

Zhang C, Yong Y, Song L, Dong X, Zhang X, Liu X . Multifunctional WS @Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer. Adv Healthc Mater. 2016; 5(21):2776-2787. DOI: 10.1002/adhm.201600633. View

14.

Bulte J, Kraitchman D . Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed. 2004; 17(7):484-99. DOI: 10.1002/nbm.924. View

15.

Moon G, Choi S, Cai X, Li W, Cho E, Jeong U . A new theranostic system based on gold nanocages and phase-change materials with unique features for photoacoustic imaging and controlled release. J Am Chem Soc. 2011; 133(13):4762-5. PMC: 3073071. DOI: 10.1021/ja200894u. View

16.

Yue H, Zhou X, Cheng M, Xing D . Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing. Nanoscale. 2017; 10(3):1063-1071. DOI: 10.1039/c7nr07999k. View

17.

Elliott M, Ravichandran K . Clearance of apoptotic cells: implications in health and disease. J Cell Biol. 2010; 189(7):1059-70. PMC: 2894449. DOI: 10.1083/jcb.201004096. View

18.

Tan L, Wang S, Xu K, Liu T, Liang P, Niu M . Layered MoS2 Hollow Spheres for Highly-Efficient Photothermal Therapy of Rabbit Liver Orthotopic Transplantation Tumors. Small. 2016; 12(15):2046-55. DOI: 10.1002/smll.201600191. View

19.

Choi S, Hoon Baek S, Chang S, Song Y, Rafique R, Lee K . Synthesis of upconversion nanoparticles conjugated with graphene oxide quantum dots and their use against cancer cell imaging and photodynamic therapy. Biosens Bioelectron. 2016; 93:267-273. DOI: 10.1016/j.bios.2016.08.094. View

20.

Hu Y, Wang R, Wang S, Ding L, Li J, Luo Y . Multifunctional Fe3O4 @ Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors. Sci Rep. 2016; 6:28325. PMC: 4914846. DOI: 10.1038/srep28325. View