Five-Year Survey of Asymptomatic Colonization with Multidrug-Resistant Organisms in a Romanian Tertiary Care Hospital

Overview

Journal Infect Drug Resist

Publisher Dove Medical Press

Date 2022 Jun 16

PMID 35706926

Authors

Daniela Talapan

Alexandru Rafila

Affiliations

Soon will be listed here.

Abstract

Purpose: To determine the rate of carriage of multidrug-resistant organisms (MDROs) between 2015 and 2019 among patients admitted to the National Institute of Infectious Diseases "Prof. Dr. Matei Balș," from Bucharest, Romania.

Methods: Nasal, throat, and rectal/perirectal screening swabs were collected either immediately or during the first 24 hours of admission and sent to the microbiology laboratory where the following MDROs were identified: methicillin-resistant (MRSA), vancomycin-resistant enterococci (VRE), extended-spectrum -lactamase (ESBL)-producing Enterobacterales, carbapenem-resistant/carbapenemase-producing Enterobacterales (CRE/CPE), multidrug-resistant/extended drug-resistant (MDR/XDR-AB), and multidrug-resistant/extended drug-resistant (MDR/XDR-PA).

Results: A total of 5083 unique patients were screened for MRSA and 5008 for VRE, ESBL/CRE/CPE, MDR/XDR-AB, and MDR/XDR-PA. MRSA was detected in 8.24% of patients, VRE in 17.67%, ESBL Enterobacterales in 25.85%, and CPE in 6.13%. MDR/XDR-AB was found in 1.59% and MDR/XDR-PA in 1.91% of patients. The rates of carriage increased between 2015 and 2019 for MRSA (7.23-7.6%), VRE (9-16.68%), CPE (1.15-6.77%), MDR/XDR-PA (1.15-1.91%), and MDR/XDR-AB (1.15-2.04%). OXA-48-type carbapenemase was predominant in (68.62%) and (89.47%). CPE bacteria other than and identified in our study carried mostly metallo-beta-lactamase (n = 28, 84.85%).

Conclusion: In this study, 37% of the unique patients screened over five years were found to be MDRO carriers. The proportion of VRE and CPE rectal carriers increased significantly between 2015 and 2019. The most frequently isolated carbapenemase was the OXA-48 type.

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