LncRNAs Are Involved in the Process of Atherosclerosis at Diverse Levels

Overview

Journal Arq Bras Cardiol

Specialty Cardiology & Vascular Diseases

Date 2022 Jun 15

PMID 35703653

Authors

Shiyi Liang

Weicheng Xv

Chijian Li

Yuxiang Huang

Ge Qian

Yuxiang Yan

Hequn Zou

Yongqiang Li

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis is the most common cause of cardiovascular disease globally, associated with a high incidence of clinical events. Accumulating evidence has elucidated that long non-coding RNAs (lncRNAs) as a novel class of transcripts with critical roles in the pathophysiological processes of atherosclerosis. In this review, we summarize the recent progress of lncRNAs in the development of atherosclerosis. We mainly describe the diverse regulatory mechanisms of lncRNAs at the transcriptional and post-transcriptional levels. This study may provide helpful insights about lncRNAs as therapeutic targets or biomarkers for atherosclerosis treatment.

Citing Articles

mRNA, miRNA, lncRNA, ceRNA: The Future of Cardiovascular Research?.

Mota G, Gatto M, Gregolin C, de Souza S, Okoshi M Arq Bras Cardiol. 2023; 120(4):e20230209.

PMID: 37194755 PMC: 10263425. DOI: 10.36660/abc.20230209.

References

Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N . Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science. 2012; 337(6097):971-5. DOI: 10.1126/science.1225237. View

Quinn J, Chang H . Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2015; 17(1):47-62. DOI: 10.1038/nrg.2015.10. View

Smith E, Prasad K, Butcher M, Dobrian A, Kolls J, Ley K . Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2010; 121(15):1746-55. PMC: 2929562. DOI: 10.1161/CIRCULATIONAHA.109.924886. View

Rapicavoli N, Qu K, Zhang J, Mikhail M, Laberge R, Chang H . A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Elife. 2013; 2:e00762. PMC: 3721235. DOI: 10.7554/eLife.00762. View

Han Y, Ma J, Wang J, Wang L . Silencing of H19 inhibits the adipogenesis and inflammation response in ox-LDL-treated Raw264.7 cells by up-regulating miR-130b. Mol Immunol. 2017; 93:107-114. DOI: 10.1016/j.molimm.2017.11.017. View

Ma L, Bajic V, Zhang Z . On the classification of long non-coding RNAs. RNA Biol. 2013; 10(6):925-33. PMC: 4111732. DOI: 10.4161/rna.24604. View

Zhou X, Han X, Wittfeldt A, Sun J, Liu C, Wang X . Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway. RNA Biol. 2015; 13(1):98-108. PMC: 4829310. DOI: 10.1080/15476286.2015.1122164. View

Cremer S, Michalik K, Fischer A, Pfisterer L, Jae N, Winter C . Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation. Circulation. 2018; 139(10):1320-1334. DOI: 10.1161/CIRCULATIONAHA.117.029015. View

van den Boom M, Sarbia M, von Wnuck Lipinski K, Mann P, Meyer-Kirchrath J, Rauch B . Differential regulation of hyaluronic acid synthase isoforms in human saphenous vein smooth muscle cells: possible implications for vein graft stenosis. Circ Res. 2005; 98(1):36-44. DOI: 10.1161/01.RES.0000199263.67107.c0. View

10.

Zhong X, Ma X, Zhang L, Li Y, Li Y, He R . MIAT promotes proliferation and hinders apoptosis by modulating miR-181b/STAT3 axis in ox-LDL-induced atherosclerosis cell models. Biomed Pharmacother. 2017; 97:1078-1085. DOI: 10.1016/j.biopha.2017.11.052. View

11.

Sussmann M, Sarbia M, Meyer-Kirchrath J, Nusing R, Schror K, Fischer J . Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. Circ Res. 2004; 94(5):592-600. DOI: 10.1161/01.RES.0000119169.87429.A0. View

12.

Chen C, Cheng G, Yang X, Li C, Shi R, Zhao N . Tanshinol suppresses endothelial cells apoptosis in mice with atherosclerosis via lncRNA TUG1 up-regulating the expression of miR-26a. Am J Transl Res. 2016; 8(7):2981-91. PMC: 4969434. View

13.

Yap K, Li S, Munoz-Cabello A, Raguz S, Zeng L, Mujtaba S . Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell. 2010; 38(5):662-74. PMC: 2886305. DOI: 10.1016/j.molcel.2010.03.021. View

14.

Holdt L, Beutner F, Scholz M, Gielen S, Gabel G, Bergert H . ANRIL expression is associated with atherosclerosis risk at chromosome 9p21. Arterioscler Thromb Vasc Biol. 2010; 30(3):620-7. DOI: 10.1161/ATVBAHA.109.196832. View

15.

Pierce J, Feinberg M . Long Noncoding RNAs in Atherosclerosis and Vascular Injury: Pathobiology, Biomarkers, and Targets for Therapy. Arterioscler Thromb Vasc Biol. 2020; 40(9):2002-2017. PMC: 7484026. DOI: 10.1161/ATVBAHA.120.314222. View

16.

Hartford C, Lal A . When Long Noncoding Becomes Protein Coding. Mol Cell Biol. 2020; 40(6). PMC: 7048269. DOI: 10.1128/MCB.00528-19. View

17.

Yu B, Wang S . Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease. Theranostics. 2018; 8(13):3654-3675. PMC: 6037039. DOI: 10.7150/thno.26024. View

18.

Tabas I, Garcia-Cardena G, Owens G . Recent insights into the cellular biology of atherosclerosis. J Cell Biol. 2015; 209(1):13-22. PMC: 4395483. DOI: 10.1083/jcb.201412052. View

19.

Pasmant E, Sabbagh A, Vidaud M, Bieche I . ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J. 2010; 25(2):444-8. DOI: 10.1096/fj.10-172452. View

20.

Arslan S, Berkan O, Lalem T, Ozbilum N, Goksel S, Korkmaz O . Long non-coding RNAs in the atherosclerotic plaque. Atherosclerosis. 2017; 266:176-181. DOI: 10.1016/j.atherosclerosis.2017.10.012. View