The LINC00261/MiR105-5p/SELL Axis is Involved in Dysfunction of B Cell and is Associated with Overall Survival in Hepatocellular Carcinoma

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2022 Jun 15

PMID 35702258

Authors

Hao Song

Xing-Feng Huang

Shu-Yang Hu

Lei-Lei Lu

Xiao-Yu Yang

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have been reported the immune dysfunction of various live tissues. However, the potential molecular mechanism of post-transcriptional regulation of immune related genes in hepatocellular carcinoma (HCC) is still not clear. We tried to identify crucial immune related biomarkers associated with HCC patients' outcomes and to reveal the transcriptional regulation.

Method: The fractions of 22 immune cells in tumor and adjacent tissues were estimated by CIBERSORT. Kruskal-Wallis test and differentially expressed analyzes were used for comparative studies. Cox proportional hazard regression model, Kaplan-Meier estimates and Log-rank test were used for survival analyses.

Results: From The Cancer Genome Atlas (TCGA), the gene, lncRNA and miRNA expression profiles of 379 HCC samples with clinical information were used for comparative studies. Eleven adaptive and innate immune cell types were significantly altered in HCC samples, including B cell memory, regulatory T cells and follicular helper T cells. Differentially expressed competing endogenous RNA (ceRNA) network associated with patients' overall survival was identified. Then, the novel pathway, including LINC00261, MiR105-5p and selectin L(SELL) was found and may be potential novel biomarkers for patients' outcomes and immunotherapy. Furthermore, SELL was significantly positively correlated (correlation coefficients: 0.47-0.69) with 12 known gene signatures of immunotherapy except for programmed cell death 1 (PDCD1).

Conclusions: Our findings could provide insights into the selection of novel LINC00261/MiR105-5p/SELL pathway which is associated with overall survival and may impact on efficacy of immunotherapy in HCC.

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References

Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z . clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation (Camb). 2021; 2(3):100141. PMC: 8454663. DOI: 10.1016/j.xinn.2021.100141. View

Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y . CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res. 2010; 38(16):5366-83. PMC: 2938198. DOI: 10.1093/nar/gkq285. View

Petitprez F, De Reynies A, Keung E, Chen T, Sun C, Calderaro J . B cells are associated with survival and immunotherapy response in sarcoma. Nature. 2020; 577(7791):556-560. DOI: 10.1038/s41586-019-1906-8. View

Li Y, Ye Y, Feng B, Qi Y . Long Noncoding RNA lncARSR Promotes Doxorubicin Resistance in Hepatocellular Carcinoma via Modulating PTEN-PI3K/Akt Pathway. J Cell Biochem. 2017; 118(12):4498-4507. DOI: 10.1002/jcb.26107. View

Newman A, Liu C, Green M, Gentles A, Feng W, Xu Y . Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015; 12(5):453-7. PMC: 4739640. DOI: 10.1038/nmeth.3337. View

Mao K, Zhang J, He C, Xu K, Liu J, Sun J . Restoration of miR-193b sensitizes Hepatitis B virus-associated hepatocellular carcinoma to sorafenib. Cancer Lett. 2014; 352(2):245-52. DOI: 10.1016/j.canlet.2014.07.004. View

Li R, Xia Y, Gao Z, Song Y, Guo Z, Yang Y . Transcriptome analysis to reveal the mechanism of the effect of Echinops latifolius polysaccharide B on palmitate-induced insulin-resistant. Biomed Pharmacother. 2021; 143:112203. DOI: 10.1016/j.biopha.2021.112203. View

Li J, Liu S, Zhou H, Qu L, Yang J . starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2013; 42(Database issue):D92-7. PMC: 3964941. DOI: 10.1093/nar/gkt1248. View

Carpenter S, Aiello D, Atianand M, Ricci E, Gandhi P, Hall L . A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013; 341(6147):789-92. PMC: 4376668. DOI: 10.1126/science.1240925. View

10.

Jin M, Zhang G, Shan C, Zhang H, Wang Z, Liu S . Up-regulation of miRNA-105 inhibits the progression of gastric carcinoma by directly targeting SOX9. Eur Rev Med Pharmacol Sci. 2019; 23(9):3779-3789. DOI: 10.26355/eurrev_201905_17804. View

11.

Zhang F, Zhang L, Zhang C . Long noncoding RNAs and tumorigenesis: genetic associations, molecular mechanisms, and therapeutic strategies. Tumour Biol. 2015; 37(1):163-75. DOI: 10.1007/s13277-015-4445-4. View

12.

Xing Y, Chen L . Processing and roles of snoRNA-ended long noncoding RNAs. Crit Rev Biochem Mol Biol. 2018; 53(6):596-606. DOI: 10.1080/10409238.2018.1508411. View

13.

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

14.

Zhu L, Yang N, Li C, Liu G, Pan W, Li X . Long noncoding RNA NEAT1 promotes cell proliferation, migration, and invasion in hepatocellular carcinoma through interacting with miR-384. J Cell Biochem. 2018; 120(2):1997-2006. PMC: 6587825. DOI: 10.1002/jcb.27499. View

15.

Takahashi K, Yan I, Wood J, Haga H, Patel T . Involvement of extracellular vesicle long noncoding RNA (linc-VLDLR) in tumor cell responses to chemotherapy. Mol Cancer Res. 2014; 12(10):1377-87. PMC: 4201956. DOI: 10.1158/1541-7786.MCR-13-0636. View

16.

Socinski M, Jotte R, Cappuzzo F, Orlandi F, Stroyakovskiy D, Nogami N . Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med. 2018; 378(24):2288-2301. DOI: 10.1056/NEJMoa1716948. View

17.

Kozomara A, Birgaoanu M, Griffiths-Jones S . miRBase: from microRNA sequences to function. Nucleic Acids Res. 2018; 47(D1):D155-D162. PMC: 6323917. DOI: 10.1093/nar/gky1141. View

18.

Yang T, He X, Chen A, Tan K, Du X . RETRACTED: LncRNA HOTAIR contributes to the malignancy of hepatocellular carcinoma by enhancing epithelial-mesenchymal transition via sponging miR-23b-3p from ZEB1. Gene. 2018; 670:114-122. DOI: 10.1016/j.gene.2018.05.061. View

19.

Tam C, Wong J, Tsui S, Zuo T, Chan T, Ng T . LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years. Appl Microbiol Biotechnol. 2019; 103(12):4649-4677. DOI: 10.1007/s00253-019-09837-5. View

20.

Liu X, Liang Y, Song R, Yang G, Han J, Lan Y . Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation. Mol Cancer. 2018; 17(1):90. PMC: 5953401. DOI: 10.1186/s12943-018-0838-5. View