Heart Rate and Age Modulate Retinal Pulsatile Patterns

Overview

Journal Commun Biol

Specialty Biology

Date 2022 Jun 14

PMID 35701487

Authors

Ivana Labounkova

Rene Labounek

Radim Kolar

Ralf P Tornow

Charles F Babbs

Collin M McClelland

Benjamin R Miller

Igor Nestrasil

Affiliations

Soon will be listed here.

Abstract

Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p < 0.05); age modulated SVP morphology (p < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.

Citing Articles

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References

LeVine D . Spontaneous pulsation of the retinal veins. Microvasc Res. 1998; 56(3):154-65. DOI: 10.1006/mvre.1998.2098. View

Feke G, Hyman B, Stern R, Pasquale L . Retinal blood flow in mild cognitive impairment and Alzheimer's disease. Alzheimers Dement (Amst). 2016; 1(2):144-51. PMC: 4876882. DOI: 10.1016/j.dadm.2015.01.004. View

Kim J, Park J, Kim D, Kim K, Jeong J, Park J . Gender Difference in Arterial Stiffness in a Multicenter Cross-Sectional Study: The Korean Arterial Aging Study (KAAS). Pulse (Basel). 2015; 2(1-4):11-7. PMC: 4646149. DOI: 10.1159/000365267. View

Golzan S, Kim M, Seddighi A, Avolio A, Graham S . Non-invasive estimation of cerebrospinal fluid pressure waveforms by means of retinal venous pulsatility and central aortic blood pressure. Ann Biomed Eng. 2012; 40(9):1940-8. DOI: 10.1007/s10439-012-0563-y. View

Heitmar R, Summers R . Assessing vascular function using dynamic retinal diameter measurements: a new insight on the endothelium. Thromb Haemost. 2012; 107(6):1019-26. DOI: 10.1160/TH11-11-0810. View

Kolar R, Tornow R, Odstrcilik J, Liberdova I . Registration of retinal sequences from new video-ophthalmoscopic camera. Biomed Eng Online. 2016; 15(1):57. PMC: 4875736. DOI: 10.1186/s12938-016-0191-0. View

Garhofer G, Bek T, Boehm A, Gherghel D, Grunwald J, Jeppesen P . Use of the retinal vessel analyzer in ocular blood flow research. Acta Ophthalmol. 2009; 88(7):717-22. DOI: 10.1111/j.1755-3768.2009.01587.x. View

Shirwany N, Zou M . Arterial stiffness: a brief review. Acta Pharmacol Sin. 2010; 31(10):1267-76. PMC: 3078647. DOI: 10.1038/aps.2010.123. View

DAntona L, McHugh J, Ricciardi F, Thorne L, Matharu M, Watkins L . Association of Intracranial Pressure and Spontaneous Retinal Venous Pulsation. JAMA Neurol. 2019; 76(12):1502-1505. PMC: 6735496. DOI: 10.1001/jamaneurol.2019.2935. View

10.

Steppan J, Barodka V, Berkowitz D, Nyhan D . Vascular stiffness and increased pulse pressure in the aging cardiovascular system. Cardiol Res Pract. 2011; 2011:263585. PMC: 3154449. DOI: 10.4061/2011/263585. View

11.

Moret F, Poloschek C, Lagreze W, Bach M . Visualization of fundus vessel pulsation using principal component analysis. Invest Ophthalmol Vis Sci. 2011; 52(8):5457-64. DOI: 10.1167/iovs.10-6806. View

12.

Levin B . The clinical significance of spontaneous pulsations of the retinal vein. Arch Neurol. 1978; 35(1):37-40. DOI: 10.1001/archneur.1978.00500250041009. View

13.

Guven D, Ozdemir H, Hasanreisoglu B . Hemodynamic alterations in diabetic retinopathy. Ophthalmology. 1996; 103(8):1245-9. DOI: 10.1016/s0161-6420(96)30514-9. View

14.

Mitchell G . Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol (1985). 2008; 105(5):1652-60. PMC: 2584844. DOI: 10.1152/japplphysiol.90549.2008. View

15.

Tornow R, Kolar R, Odstrcilik J, Labounkova I, Horn F . Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head. Graefes Arch Clin Exp Ophthalmol. 2020; 259(2):483-494. PMC: 7843566. DOI: 10.1007/s00417-020-04934-y. View

16.

Wang X, Jiang C, Ko T, Kong X, Yu X, Min W . Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study. Graefes Arch Clin Exp Ophthalmol. 2015; 253(9):1557-64. DOI: 10.1007/s00417-015-3095-y. View

17.

Jan J, Odstrcilik J, Gazarek J, Kolar R . Retinal image analysis aimed at blood vessel tree segmentation and early detection of neural-layer deterioration. Comput Med Imaging Graph. 2012; 36(6):431-41. DOI: 10.1016/j.compmedimag.2012.04.006. View

18.

Holwerda S, Kardon R, Hashimoto R, Full J, Nellis J, DuBose L . Aortic stiffness is associated with changes in retinal arteriole flow pulsatility mediated by local vasodilation in healthy young/middle-age adults. J Appl Physiol (1985). 2020; 129(1):84-93. PMC: 7469231. DOI: 10.1152/japplphysiol.00252.2020. View

19.

DeBuc D, Rege A, Smiddy W . Use of XyCAM RI for Noninvasive Visualization and Analysis of Retinal Blood Flow Dynamics During Clinical Investigations. Expert Rev Med Devices. 2021; 18(3):225-237. DOI: 10.1080/17434440.2021.1892486. View

20.

Betz-Stablein B, Hazelton M, Morgan W . Modelling retinal pulsatile blood flow from video data. Stat Methods Med Res. 2016; 27(5):1575-1584. DOI: 10.1177/0962280216665504. View