Recent Developments and Advances in Atopic Dermatitis: A Focus on Epidemiology, Pathophysiology, and Treatment in the Pediatric Setting

Overview

Journal Paediatr Drugs

Specialties Pediatrics
Pharmacology

Date 2022 Jun 13

PMID 35698002

Authors

Lawrence F Eichenfield

Stephen Stripling

Selwyn Fung

Amy Cha

Andryann OBrien

Lawrence A Schachner

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects a substantial number of children and has a significant negative impact on affected patients and their caregivers/families. Recent studies have led to significant evolutions in the understanding of AD pathogenesis, epidemiology, and treatment. The first point of contact for many patients with new-onset AD is usually with their primary care provider or pediatrician. This underscores the importance for pediatricians to understand the basic pathophysiology and current standards of care for AD. This article provides up-to-date information and reviews the basic principles of AD pathophysiology, diagnosis, and management. In addition, the article highlights recent advances in scientific research regarding the mechanisms involved in the pathogenesis of atopic dermatitis that have resulted in the discovery of novel therapeutic targets and the development of targeted biologic therapies with the potential to revolutionize AD therapy.

Citing Articles

Managing Childhood and Adolescent Atopic Dermatitis in Primary Care: A US Expert Group Consensus.

Boguniewicz M, Levy M, Eichenfield L, Lauren C, Leung D, Schneider L J Pediatr Clin Pract. 2025; 14:200121.

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Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema.

Li Y, Wang Z, Li X, Ma K, Shi Z Arch Dermatol Res. 2025; 317(1):375.

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Differential Expression of Proteins Involved in Skin Barrier Maintenance and Vitamin D Metabolism in Atopic Dermatitis: A Cross-Sectional, Exploratory Study.

Grieco T, Paolino G, Moliterni E, Chello C, Sernicola A, Egan C Int J Mol Sci. 2025; 26(1.

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The Impact of Immune Cells, Metabolites, Inflammatory Factors, and Circulating Proteins on Atopic Dermatitis: Insights from a Mendelian Randomization Study.

Zhou D, Gan G, Song S, Zi C, Bao Y, Hao W Clin Cosmet Investig Dermatol. 2024; 17:2999-3011.

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References

Silverberg J, Simpson E . Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization. Pediatr Allergy Immunol. 2013; 24(5):476-86. PMC: 4397968. DOI: 10.1111/pai.12095. View

Nutten S . Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab. 2015; 66 Suppl 1:8-16. DOI: 10.1159/000370220. View

Eichenfield L, Tom W, Chamlin S, Feldman S, Hanifin J, Simpson E . Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2013; 70(2):338-51. PMC: 4410183. DOI: 10.1016/j.jaad.2013.10.010. View

Wang J, Ramette A, Jurca M, Goutaki M, Beardsmore C, Kuehni C . Association between breastfeeding and eczema during childhood and adolescence: A cohort study. PLoS One. 2017; 12(9):e0185066. PMC: 5612686. DOI: 10.1371/journal.pone.0185066. View

Bylund S, Kobyletzki L, Svalstedt M, Svensson A . Prevalence and Incidence of Atopic Dermatitis: A Systematic Review. Acta Derm Venereol. 2020; 100(12):adv00160. PMC: 9189744. DOI: 10.2340/00015555-3510. View

Silverberg J . Public Health Burden and Epidemiology of Atopic Dermatitis. Dermatol Clin. 2017; 35(3):283-289. DOI: 10.1016/j.det.2017.02.002. View

Drucker A, Wang A, Li W, Sevetson E, Block J, Qureshi A . The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. J Invest Dermatol. 2016; 137(1):26-30. DOI: 10.1016/j.jid.2016.07.012. View

Chung J, Simpson E . The socioeconomics of atopic dermatitis. Ann Allergy Asthma Immunol. 2019; 122(4):360-366. DOI: 10.1016/j.anai.2018.12.017. View

Al-Naqeeb J, Danner S, Fagnan L, Ramsey K, Michaels L, Mitchell J . The Burden of Childhood Atopic Dermatitis in the Primary Care Setting: A Report from the Meta-LARC Consortium. J Am Board Fam Med. 2019; 32(2):191-200. DOI: 10.3122/jabfm.2019.02.180225. View

10.

Abuabara K, Margolis D, Langan S . The Long-Term Course of Atopic Dermatitis. Dermatol Clin. 2017; 35(3):291-297. PMC: 5612374. DOI: 10.1016/j.det.2017.02.003. View

11.

Bantz S, Zhu Z, Zheng T . The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma. J Clin Cell Immunol. 2014; 5(2). PMC: 4240310. DOI: 10.4172/2155-9899.1000202. View

12.

Strom M, Fishbein A, Paller A, Silverberg J . Association between atopic dermatitis and attention deficit hyperactivity disorder in U.S. children and adults. Br J Dermatol. 2016; 175(5):920-929. PMC: 5216180. DOI: 10.1111/bjd.14697. View

13.

Yaghmaie P, Koudelka C, Simpson E . Mental health comorbidity in patients with atopic dermatitis. J Allergy Clin Immunol. 2012; 131(2):428-33. PMC: 3565469. DOI: 10.1016/j.jaci.2012.10.041. View

14.

Tsakok T, Marrs T, Mohsin M, Baron S, Du Toit G, Till S . Does atopic dermatitis cause food allergy? A systematic review. J Allergy Clin Immunol. 2016; 137(4):1071-1078. DOI: 10.1016/j.jaci.2015.10.049. View

15.

Novak N, Bieber T, Leung D . Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol. 2003; 112(6 Suppl):S128-39. DOI: 10.1016/j.jaci.2003.09.032. View

16.

Malik K, Heitmiller K, Czarnowicki T . An Update on the Pathophysiology of Atopic Dermatitis. Dermatol Clin. 2017; 35(3):317-326. DOI: 10.1016/j.det.2017.02.006. View

17.

Wollina U . Microbiome in atopic dermatitis. Clin Cosmet Investig Dermatol. 2017; 10:51-56. PMC: 5327846. DOI: 10.2147/CCID.S130013. View

18.

Rerknimitr P, Otsuka A, Nakashima C, Kabashima K . The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus. Inflamm Regen. 2017; 37:14. PMC: 5725646. DOI: 10.1186/s41232-017-0044-7. View

19.

Bin L, Leung D . Genetic and epigenetic studies of atopic dermatitis. Allergy Asthma Clin Immunol. 2016; 12:52. PMC: 5069938. DOI: 10.1186/s13223-016-0158-5. View

20.

Powers C, McShane D, Gilligan P, Burkhart C, Morrell D . Microbiome and pediatric atopic dermatitis. J Dermatol. 2015; 42(12):1137-42. DOI: 10.1111/1346-8138.13072. View