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Can the Personalized Medicine Approach Contribute in Controlling Tuberculosis in General and India in Particular?

Overview
Journal Precis Clin Med
Specialty General Medicine
Date 2022 Jun 13
PMID 35694414
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Abstract

Poor drug compliance and drug-resistant are the two principal obstacles in controlling tuberculosis (TB) in endemic regions including India, which has contributed the most to global TB burden. We argue here that a personalized medicine approach, to start with the -acetyl transferase-2-isoniazid (NAT2-INH) model, could be a step forward in dealing with both these limitations in controlling TB in India.

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References
1.
Chatterjee S, Poonawala H, Jain Y . Drug-resistant tuberculosis: is India ready for the challenge?. BMJ Glob Health. 2018; 3(4):e000971. PMC: 6089296. DOI: 10.1136/bmjgh-2018-000971. View

2.
Wang J, Tang S, Shen H . Association of genetic polymorphisms in the IL12-IFNG pathway with susceptibility to and prognosis of pulmonary tuberculosis in a Chinese population. Eur J Clin Microbiol Infect Dis. 2010; 29(10):1291-5. DOI: 10.1007/s10096-010-0985-0. View

3.
Khan N, Pande V, Das A . NAT2 sequence polymorphisms and acetylation profiles in Indians. Pharmacogenomics. 2013; 14(3):289-303. DOI: 10.2217/pgs.13.2. View

4.
Rao V, Bhat J, Yadav R, Muniyandi M, Sharma R, Bhondeley M . Pulmonary tuberculosis - a health problem amongst Saharia tribe in Madhya Pradesh. Indian J Med Res. 2015; 141(5):630-5. PMC: 4510762. DOI: 10.4103/0971-5916.159560. View

5.
Wlodarska M, Johnston J, Gardy J, Tang P . A microbiological revolution meets an ancient disease: improving the management of tuberculosis with genomics. Clin Microbiol Rev. 2015; 28(2):523-39. PMC: 4402953. DOI: 10.1128/CMR.00124-14. View