Is It Necessary to Target Lipid Metabolism in Different Organs for Effective Treatment of NASH?-the Results of the Pan-PPAR Lanifibranor Trial

Overview

Journal Hepatobiliary Surg Nutr

Publisher AME Publishing Company

Date 2022 Jun 13

PMID 35693392

Authors

Amalia Gastaldelli

Affiliations

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References

Guerra S, Mocciaro G, Gastaldelli A . Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis. Eur J Clin Invest. 2021; 52(3):e13695. DOI: 10.1111/eci.13695. View

Liu X, Xu J, Rosenthal S, Zhang L, McCubbin R, Meshgin N . Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Gastroenterology. 2020; 158(6):1728-1744.e14. PMC: 7252905. DOI: 10.1053/j.gastro.2020.01.027. View

Forman B, Chen J, Evans R . Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A. 1997; 94(9):4312-7. PMC: 20719. DOI: 10.1073/pnas.94.9.4312. View

Gastaldelli A, Stefan N, Haring H . Liver-targeting drugs and their effect on blood glucose and hepatic lipids. Diabetologia. 2021; 64(7):1461-1479. PMC: 8187191. DOI: 10.1007/s00125-021-05442-2. View

Gastaldelli A, Sabatini S, Carli F, Gaggini M, Bril F, Belfort-DeAguiar R . PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH. Liver Int. 2021; 41(11):2659-2670. PMC: 9290929. DOI: 10.1111/liv.15005. View