Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel Cortex

Overview

Journal Basic Clin Neurosci

Specialty Neurology

Date 2022 Jun 13

PMID 35693139

Authors

Mahin Nasiri

Ayat Kaeidi

Iman Fatemi

Mahdieh Azin

Mahboobeh Bannazadeh

Mohammad Allahtavakoli

Ali Roohbakhsh

Ali Shamsizadeh

Affiliations

Soon will be listed here.

Abstract

Introduction: Memantine as N-Methyl-D-Aspartic Acid (NMDA) receptor antagonist is used in some neurological disorders. Moreover, memantine presents modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effects of memantine on electrophysiological properties of barrel cortex neurons in male rats.

Methods: Single unit recording was used to evaluate the electrophysiological properties of barrel cortex neurons. The neural responses to the Principal Whisker (PW), Adjacent Whisker (AW), and combined displacement of two whiskers [20 ms Inter-Stimulus Intervals (ISIs)] were recorded before and 2 hours after memantine gavage (10 mg/kg). A Condition Test Ratio (CTR) was calculated for assessing inhibitory interactions.

Results: Two hours after memantine gavage, neuronal ON and OFF responses to PW deflection were decreased. Furthermore, CTR for both ON and OFF responses was decreased following memantine administration.

Conclusion: The current study demonstrated that memantine modified neural response properties in the rat barrel cortex.

Highlights: Memantine modulated excitatory receptive fields in the rat somatosensory cortex.Memantine decreased integrative receptive fields in rat somatosensory cortex.

Plain Language Summary: As an NMDA receptor antagonist, memantine is used to treat moderate to severe Alzheimer's disease. Memantine has beneficial effects on cognition, mood, and perform daily activities. However, the current study results suggested that memantine may affect information processing in the somatosensory system. This should be considered for future research in the clinic.

References

Nussbaumer J, Van Der Loos H . An electrophysiological and anatomical study of projections to the mouse cortical barrelfield and its surroundings. J Neurophysiol. 1985; 53(3):686-98. DOI: 10.1152/jn.1985.53.3.686. View

Lee S, Kim S, Noh Y, Choi B, Noh G, Park W . Pharmacokinetics of Memantine after a Single and Multiple Dose of Oral and Patch Administration in Rats. Basic Clin Pharmacol Toxicol. 2015; 118(2):122-7. DOI: 10.1111/bcpt.12479. View

Armstrong-James M, Welker E, Callahan C . The contribution of NMDA and non-NMDA receptors to fast and slow transmission of sensory information in the rat SI barrel cortex. J Neurosci. 1993; 13(5):2149-60. PMC: 6576573. View

Bradley R, Mardian E, Bloemberg D, Aristizabal Henao J, Mitchell A, Marvyn P . Mice Deficient in (δ)/ () Have Impaired Learning and Memory. Mol Cell Biol. 2017; 37(22). PMC: 5660461. DOI: 10.1128/MCB.00245-17. View

Kimura A, Namekata K, Guo X, Harada C, Harada T . Dock3-NMDA receptor interaction as a target for glaucoma therapy. Histol Histopathol. 2016; 32(3):215-221. DOI: 10.14670/HH-11-820. View

Dinse H, Ragert P, Pleger B, Schwenkreis P, Tegenthoff M . Pharmacological modulation of perceptual learning and associated cortical reorganization. Science. 2003; 301(5629):91-4. DOI: 10.1126/science.1085423. View

Simons D, Carvell G . Thalamocortical response transformation in the rat vibrissa/barrel system. J Neurophysiol. 1989; 61(2):311-30. DOI: 10.1152/jn.1989.61.2.311. View

Demontis F, Falconi M, Canu D, Serra G . Memantine prevents "bipolar-like" behavior induced by chronic treatment with imipramine in rats. Eur J Pharmacol. 2015; 752:49-54. DOI: 10.1016/j.ejphar.2015.01.041. View

van Marum R . Update on the use of memantine in Alzheimer's disease. Neuropsychiatr Dis Treat. 2009; 5:237-47. PMC: 2695219. DOI: 10.2147/ndt.s4048. View

10.

Stuttgen M, Schwarz C . Barrel cortex: What is it good for?. Neuroscience. 2017; 368:3-16. DOI: 10.1016/j.neuroscience.2017.05.009. View

11.

Fox K, Wright N, Wallace H, Glazewski S . The origin of cortical surround receptive fields studied in the barrel cortex. J Neurosci. 2003; 23(23):8380-91. PMC: 6740706. View

12.

Martinak B, Bolis R, Black J, Fargason R, Birur B . Dextromethorphan in Cough Syrup: The Poor Man's Psychosis. Psychopharmacol Bull. 2017; 47(4):59-63. PMC: 5601090. View

13.

Motaghi S, Sheibani V, Farazifard R, Joneidi H . Electrical stimulation of locus coeruleus strengthens the surround inhibition in layer V barrel cortex in rat. Neurosci Lett. 2006; 401(3):280-4. DOI: 10.1016/j.neulet.2006.03.034. View

14.

Johnson J, Kotermanski S . Mechanism of action of memantine. Curr Opin Pharmacol. 2005; 6(1):61-7. DOI: 10.1016/j.coph.2005.09.007. View

15.

Makhaeva G, Lushchekina S, Boltneva N, Sokolov V, Grigoriev V, Serebryakova O . Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease. Sci Rep. 2015; 5:13164. PMC: 4642525. DOI: 10.1038/srep13164. View

16.

Barnes C, Danysz W, Parsons C . Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats. Eur J Neurosci. 1996; 8(3):565-71. DOI: 10.1111/j.1460-9568.1996.tb01241.x. View

17.

Ego-Stengel V, Mello E Souza T, Jacob V, Shulz D . Spatiotemporal characteristics of neuronal sensory integration in the barrel cortex of the rat. J Neurophysiol. 2004; 93(3):1450-67. DOI: 10.1152/jn.00912.2004. View

18.

Simons D, Land P . Early experience of tactile stimulation influences organization of somatic sensory cortex. Nature. 1987; 326(6114):694-7. DOI: 10.1038/326694a0. View

19.

Pringle A, Parsons E, Cowen L, McTavish S, Cowen P, Harmer C . Using an experimental medicine model to understand the antidepressant potential of the N-Methyl-D-aspartic acid (NMDA) receptor antagonist memantine. J Psychopharmacol. 2012; 26(11):1417-23. PMC: 3546643. DOI: 10.1177/0269881112446535. View

20.

Shamsizadeh A, Sheibani V, Arabzadeh S, Afarinesh M, Farazifard R, Noorbakhsh S . Single whisker experience started on postnatal days 0, 5 or 8 changes temporal characteristics of response integration in layers IV and V of rat barrel cortex neurons. Brain Res Bull. 2007; 74(1-3):29-36. DOI: 10.1016/j.brainresbull.2007.04.010. View