The Role of LncRNAs in the Regulation of Radiotherapy Sensitivity in Cervical Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Jun 13

PMID 35692795

Authors

Hanqun Zhang

Chunju Fang

Zhiyu Feng

Tingting Xia

Liang Lu

Min Luo

Yanping Chen

Yuncong Liu

Yong Li

Affiliations

Soon will be listed here.

Abstract

Cervical cancer (CC) is one of the three majors gynecological malignancies, which seriously threatens women's health and life. Radiotherapy (RT) is one of the most common treatments for cervical cancer, which can reduce local recurrence and prolong survival in patients with cervical cancer. However, the resistance of cancer cells to Radiotherapy are the main cause of treatment failure in patients with cervical cancer. Long non-coding RNAs (LncRNAs) are a group of non-protein-coding RNAs with a length of more than 200 nucleotides, which play an important role in regulating the biological behavior of cervical cancer. Recent studies have shown that LncRNAs play a key role in regulating the sensitivity of radiotherapy for cervical cancer. In this review, we summarize the structure and function of LncRNAs and the molecular mechanism of radiosensitivity in cervical cancer, list the LncRNAs associated with radiosensitivity in cervical cancer, analyze their potential mechanisms, and discuss the potential clinical application of these LncRNAs in regulating radiosensitivity in cervical cancer.

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References

Ge X, Gu Y, Li D, Jiang M, Zhao S, Li Z . Knockdown of lncRNA PCAT1 Enhances Radiosensitivity of Cervical Cancer by Regulating miR-128/GOLM1 Axis. Onco Targets Ther. 2020; 13:10373-10385. PMC: 7568621. DOI: 10.2147/OTT.S263728. View

Wang Y, Chen W, Yang C, Wu W, Wu S, Qin X . Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. Int J Oncol. 2012; 41(1):276-84. DOI: 10.3892/ijo.2012.1443. View

ROTH D, Porter T, Wilson J . Mechanisms of nonhomologous recombination in mammalian cells. Mol Cell Biol. 1985; 5(10):2599-607. PMC: 366995. DOI: 10.1128/mcb.5.10.2599-2607.1985. View

Zou Y, Yao S, Chen X, Liu D, Wang J, Yuan X . LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells. Eur J Cell Biol. 2018; 97(5):369-378. DOI: 10.1016/j.ejcb.2018.04.005. View

Shimura T, Noma N, Sano Y, Ochiai Y, Oikawa T, Fukumoto M . AKT-mediated enhanced aerobic glycolysis causes acquired radioresistance by human tumor cells. Radiother Oncol. 2014; 112(2):302-7. DOI: 10.1016/j.radonc.2014.07.015. View

Novikova I, Hennelly S, Sanbonmatsu K . Structural architecture of the human long non-coding RNA, steroid receptor RNA activator. Nucleic Acids Res. 2012; 40(11):5034-51. PMC: 3367176. DOI: 10.1093/nar/gks071. View

Han Q, Li L, Liang H, Li Y, Xie J, Wang Z . Downregulation of lncRNA X Inactive Specific Transcript (XIST) Suppresses Cell Proliferation and Enhances Radiosensitivity by Upregulating mir-29c in Nasopharyngeal Carcinoma Cells. Med Sci Monit. 2017; 23:4798-4807. PMC: 5642646. DOI: 10.12659/msm.905370. View

Chen L, Yuan D, Yang Y, Ren M . LincRNA-p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β-catenin signaling pathway. J Cell Biochem. 2018; 120(4):6178-6187. DOI: 10.1002/jcb.27905. View

Kitagawa R, Kastan M . The ATM-dependent DNA damage signaling pathway. Cold Spring Harb Symp Quant Biol. 2006; 70:99-109. DOI: 10.1101/sqb.2005.70.002. View

10.

Tian R, Zhang C, Xiong F, Chen H . PCAT1/miR-129/ABCB1 axis confers chemoresistance in non-small cell lung cancer. Front Biosci (Landmark Ed). 2020; 25(5):948-960. DOI: 10.2741/4842. View

11.

Fatica A, Bozzoni I . Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet. 2013; 15(1):7-21. DOI: 10.1038/nrg3606. View

12.

Dai Q, Zhang T, Pan J, Li C . LncRNA UCA1 promotes cisplatin resistance in gastric cancer via recruiting EZH2 and activating PI3K/AKT pathway. J Cancer. 2020; 11(13):3882-3892. PMC: 7171500. DOI: 10.7150/jca.43446. View

13.

Yan Q, Tian Y, Hao F . Downregulation of lncRNA UCA1 inhibits proliferation and invasion of cervical cancer cells through miR-206 expression. Oncol Res. 2018; . DOI: 10.3727/096504018X15185714083446. View

14.

Zou Z, Chang H, Li H, Wang S . Induction of reactive oxygen species: an emerging approach for cancer therapy. Apoptosis. 2017; 22(11):1321-1335. DOI: 10.1007/s10495-017-1424-9. View

15.

Zhao H, Zheng G, Li G, Xin L, Wang Y, Chen Y . Long noncoding RNA LINC00958 regulates cell sensitivity to radiotherapy through RRM2 by binding to microRNA-5095 in cervical cancer. J Cell Physiol. 2019; 234(12):23349-23359. DOI: 10.1002/jcp.28902. View

16.

Lee J . Epigenetic regulation by long noncoding RNAs. Science. 2012; 338(6113):1435-9. DOI: 10.1126/science.1231776. View

17.

Birney E, Stamatoyannopoulos J, Dutta A, Guigo R, Gingeras T, Margulies E . Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007; 447(7146):799-816. PMC: 2212820. DOI: 10.1038/nature05874. View

18.

Jing L, Yuan W, Ruofan D, Jinjin Y, Haifeng Q . HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer. Tumour Biol. 2014; 36(5):3611-9. DOI: 10.1007/s13277-014-2998-2. View

19.

Yoon J, Abdelmohsen K, Gorospe M . Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol. 2012; 425(19):3723-30. PMC: 3594629. DOI: 10.1016/j.jmb.2012.11.024. View

20.

Jiang W, Wu Y, He T, Zhu H, Ke G, Xiang L . Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the -E545K Mutation. Mol Cancer Ther. 2019; 19(2):337-347. DOI: 10.1158/1535-7163.MCT-19-0309. View