Extracellular Vesicles and Hepatocellular Carcinoma: Opportunities and Challenges

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Jun 13

PMID 35692794

Authors

Juan Wang

Xiaoya Wang

Xintong Zhang

Tingting Shao

Yanmei Luo

Wei Wang

Yunwei Han

Affiliations

Soon will be listed here.

Abstract

The incidence of hepatocellular carcinoma (HCC) is increasing worldwide. Extracellular vesicles (EVs) contain sufficient bioactive substances and are carriers of intercellular information exchange, as well as delivery vehicles for nucleic acids, proteins and drugs. Although EVs show great potential for the treatment of HCC and their role in HCC progression has been extensively studied, there are still many challenges such as time-consuming extraction, difficult storage, easy contamination, and low drug loading rate. We focus on the biogenesis, morphological characteristics, isolation and extraction of EVs and their significance in the progression of HCC, tumor invasion, immune escape and cancer therapy for a review. EVs may be effective biomarkers for molecular diagnosis of HCC and new targets for tumor-targeted therapy.

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