Long Intergenic Noncoding RNA00265 Enhances Cell Viability and Metastasis Targeting MiR-485-5p/USP22 Axis in Osteosarcoma

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Jun 13

PMID 35692754

Authors

Ting Chen

Jinxin Liu

He Zhang

Jiatong Li

Guanning Shang

Affiliations

Soon will be listed here.

Abstract

Osteosarcoma is one of the bone malignancies in children and adolescents. Long noncoding RNAs (lncRNAs) have been demonstrated to participate in osteosarcoma development and progression. Linc00265 has been shown to involve in osteosarcoma oncogenesis; however, the underlying mechanism is largely unclear. In this study, we investigated the function of linc00265 in osteosarcoma cells, including cell viability, migration and invasion. Moreover, we elucidated mechanistically the involvement of linc00265 in osteosarcoma. We found that linc00265 overexpression promoted viability, migration and invasion of osteosarcoma cells. Notably, linc00265 sponged miR-485-5p and increased the expression of USP22, one target of miR-485-5p, in osteosarcoma cells. Strikingly, linc00265 exerted its oncogenic function regulating miR-485-5p and USP22 in osteosarcoma. Taken together, targeting linc00265 is a promising approach for treating osteosarcoma patients.

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