Neural Consequences of Chronic Sleep Disruption

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2022 Jun 12

PMID 35691776

Authors

Zachary Zamore

Sigrid C Veasey

Affiliations

Soon will be listed here.

Abstract

Recent studies in both humans and animal models call into question the completeness of recovery after chronic sleep disruption. Studies in humans have identified cognitive domains particularly vulnerable to delayed or incomplete recovery after chronic sleep disruption, including sustained vigilance and episodic memory. These findings, in turn, provide a focus for animal model studies to critically test the lasting impact of sleep loss on the brain. Here, we summarize the human response to sleep disruption and then discuss recent findings in animal models examining recovery responses in circuits pertinent to vigilance and memory. We then propose pathways of injury common to various forms of sleep disruption and consider the implications of this injury in aging and in neurodegenerative disorders.

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