Gut Virome in Early Life: Origins and Implications

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2022 Jun 11

PMID 35690009

Authors

Elizabeth A Kennedy

Lori R Holtz

Affiliations

Soon will be listed here.

Abstract

The human body is colonized by a multitude of bacteria, fungi, and viruses, which play important roles in health and disease. Microbial colonization during early life is thought to be a particularly important period with lasting consequences for health. Viral populations in the gut are particularly dynamic in early life before they stabilize in adulthood. The composition of the early-life virome is increasingly recognized as a determinant of disease later in life. Here, we review the development of the virome in healthy infants, as well as the role of the early-life virome in the development of disease states including diarrhea, malnutrition, and autoimmune diseases.

Citing Articles

Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies.

Pirker A, Vogl T Front Allergy. 2024; 5:1439303.

PMID: 39086886 PMC: 11288972. DOI: 10.3389/falgy.2024.1439303.

Multiple micronutrient deficiencies in early life cause multi-kingdom alterations in the gut microbiome and intrinsic antibiotic resistance genes in mice.

Littlejohn P, Metcalfe-Roach A, Cardenas Poire E, Holani R, Bar-Yoseph H, Fan Y Nat Microbiol. 2023; 8(12):2392-2405.

PMID: 37973864 DOI: 10.1038/s41564-023-01519-3.

The Underrated Gut Microbiota Helminths, Bacteriophages, Fungi, and Archaea.

Garcia-Bonete M, Rajan A, Suriano F, Layunta E Life (Basel). 2023; 13(8).

PMID: 37629622 PMC: 10455619. DOI: 10.3390/life13081765.

Viral metagenomics of the gut virome of diarrheal children with Rotavirus A infection.

Bao S, Wang H, Li W, Wu H, Lu C, Yong L Gut Microbes. 2023; 15(1):2234653.

PMID: 37448101 PMC: 10351451. DOI: 10.1080/19490976.2023.2234653.

The Human Gut Virome and Its Relationship with Nontransmissible Chronic Diseases.

Ezzatpour S, Mondragon Portocarrero A, Cardelle-Cobas A, Lamas A, Lopez-Santamarina A, Miranda J Nutrients. 2023; 15(4).

PMID: 36839335 PMC: 9960951. DOI: 10.3390/nu15040977.

References

Lim E, Rodriguez C, Holtz L . Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community. Microbiome. 2018; 6(1):87. PMC: 5946436. DOI: 10.1186/s40168-018-0475-7. View

Yeung W, Rawlinson W, Craig M . Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies. BMJ. 2011; 342:d35. PMC: 3033438. DOI: 10.1136/bmj.d35. View

Ifie E, Russell M, Dhayal S, Leete P, Sebastiani G, Nigi L . Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia. 2018; 61(11):2344-2355. PMC: 6182664. DOI: 10.1007/s00125-018-4704-1. View

Liang G, Cobian-Guemes A, Albenberg L, Bushman F . The gut virome in inflammatory bowel diseases. Curr Opin Virol. 2021; 51:190-198. DOI: 10.1016/j.coviro.2021.10.005. View

Phan T, Vo N, Bonkoungou I, Kapoor A, Barro N, ORyan M . Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus. J Virol. 2012; 86(20):11024-30. PMC: 3457132. DOI: 10.1128/JVI.01427-12. View

Siebrasse E, Reyes A, Lim E, Zhao G, Mkakosya R, Manary M . Identification of MW polyomavirus, a novel polyomavirus in human stool. J Virol. 2012; 86(19):10321-6. PMC: 3457274. DOI: 10.1128/JVI.01210-12. View

Lebwohl B, Sanders D, Green P . Coeliac disease. Lancet. 2017; 391(10115):70-81. DOI: 10.1016/S0140-6736(17)31796-8. View

. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Infect Dis. 2018; 18(11):1211-1228. PMC: 6202444. DOI: 10.1016/S1473-3099(18)30362-1. View

Pannaraj P, Ly M, Cerini C, Saavedra M, Aldrovandi G, Saboory A . Shared and Distinct Features of Human Milk and Infant Stool Viromes. Front Microbiol. 2018; 9:1162. PMC: 5992295. DOI: 10.3389/fmicb.2018.01162. View

10.

Chu D, Poon L, Chiu S, Chan K, Ng E, Bauer I . Characterization of a novel gyrovirus in human stool and chicken meat. J Clin Virol. 2012; 55(3):209-13. PMC: 3449218. DOI: 10.1016/j.jcv.2012.07.001. View

11.

Ng T, Zhang W, Sachsenroder J, Kondov N, da Costa A, Vega E . A diverse group of small circular ssDNA viral genomes in human and non-human primate stools. Virus Evol. 2016; 1(1):vev017. PMC: 5014484. DOI: 10.1093/ve/vev017. View

12.

Bushman F, Liang G . Assembly of the virome in newborn human infants. Curr Opin Virol. 2021; 48:17-22. PMC: 8187319. DOI: 10.1016/j.coviro.2021.03.004. View

13.

El Mouzan M, Assiri A, Al Sarkhy A, Alasmi M, Saeed A, Al-Hussaini A . Viral dysbiosis in children with new-onset celiac disease. PLoS One. 2022; 17(1):e0262108. PMC: 8759644. DOI: 10.1371/journal.pone.0262108. View

14.

Marild K, Kahrs C, Tapia G, Stene L, Stordal K . Infections and risk of celiac disease in childhood: a prospective nationwide cohort study. Am J Gastroenterol. 2015; 110(10):1475-84. DOI: 10.1038/ajg.2015.287. View

15.

Dolcino M, Zanoni G, Bason C, Tinazzi E, Boccola E, Valletta E . A subset of anti-rotavirus antibodies directed against the viral protein VP7 predicts the onset of celiac disease and induces typical features of the disease in the intestinal epithelial cell line T84. Immunol Res. 2013; 56(2-3):465-76. DOI: 10.1007/s12026-013-8420-0. View

16.

Smits S, Rahman M, Schapendonk C, van Leeuwen M, Faruque A, Haagmans B . Calicivirus from novel Recovirus genogroup in human diarrhea, Bangladesh. Emerg Infect Dis. 2012; 18(7):1192-5. PMC: 3376821. DOI: 10.3201/eid1807.120344. View

17.

Kim A, Armah G, Dennis F, Wang L, Rodgers R, Droit L . Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of Ghanaian infants. Cell Host Microbe. 2021; 30(1):110-123.e5. PMC: 8763403. DOI: 10.1016/j.chom.2021.12.002. View

18.

Kapoor A, Li L, Victoria J, Oderinde B, Mason C, Pandey P . Multiple novel astrovirus species in human stool. J Gen Virol. 2009; 90(Pt 12):2965-2972. PMC: 2796194. DOI: 10.1099/vir.0.014449-0. View

19.

Eringsmark Regnell S, Lernmark A . The environment and the origins of islet autoimmunity and Type 1 diabetes. Diabet Med. 2012; 30(2):155-60. PMC: 3552102. DOI: 10.1111/dme.12099. View

20.

McCann A, Ryan F, Stockdale S, Dalmasso M, Blake T, Ryan C . Viromes of one year old infants reveal the impact of birth mode on microbiome diversity. PeerJ. 2018; 6:e4694. PMC: 5944432. DOI: 10.7717/peerj.4694. View