Interaction Between M6A Methylation and Noncoding RNA in Glioma

Overview

Journal Cell Death Discov

Date 2022 Jun 10

PMID 35688823

Authors

Nairong Tao

Tongxuan Wen

Tong Li

Lan Luan

Hai Pan

Yong Wang

Affiliations

Soon will be listed here.

Abstract

Glioma is considered to be the most common brain malignancy in the central nervous system. At present, the aetiology of glioma is not clear. Due to its rapidly growth and easily recurrence, the prognosis of patients with glioma is very poor. N6-methyladenosine (m6A) methylation is an internal reversible modification in most RNAs, including messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). Recent studies have shown that the m6A regulators are abnormal expressed, and are extensively involved in the progression of glioma by targeting ncRNAs. Moreover, as the most important epigenetic regulators, ncRNAs can also affect the function of m6A regulators in glioma. This review summarized the expression and function of certain common m6A regulators in glioma. Also, the current review sum up the mutual interactions between m6A regulators and ncRNAs in glioma.

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