Some Thoughts About What Non-mammalian Jawed Vertebrates Are Telling Us About Antigen Processing and Peptide loading of MHC Molecules

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2022 Jun 10

PMID 35687979

Authors

Rebecca Martin

Jim Kaufman

Affiliations

Soon will be listed here.

Abstract

The major histocompatibility complex (MHC) of mammals encodes highly polymorphic classical class I and class II molecules with crucial roles in immune responses, as well as various nonclassical molecules encoded by the MHC and elsewhere in the genome that have a variety of functions. These MHC molecules are supported by antigen processing and peptide loading pathways which are well-understood in mammals. This review considers what has been learned about the MHC, MHC molecules and the supporting pathways in non-mammalian jawed vertebrates. From the initial understanding from work with the chicken MHC, a great deal of diversity in the structure and function has been found. Are there underlying principles?

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