Metabolic Actions of the Growth Hormone-insulin Growth Factor-1 Axis and Its Interaction with the Central Nervous System

Overview

Journal Rev Endocr Metab Disord

Publisher Springer

Specialty Endocrinology

Date 2022 Jun 10

PMID 35687272

Authors

Omar Al-Massadi

Paolo Parini

Johan Ferno

Serge Luquet

Mar Quinones

Affiliations

Soon will be listed here.

Abstract

The growth hormone/insulin growth factor-1 axis is a key endocrine system that exerts profound effects on metabolism by its actions on different peripheral tissues but also in the brain. Growth hormone together with insulin growth factor-1 perform metabolic adjustments, including regulation of food intake, energy expenditure, and glycemia. The dysregulation of this hepatic axis leads to different metabolic disorders including obesity, type 2 diabetes or liver disease. In this review, we discuss how the growth hormone/insulin growth factor-1 axis regulates metabolism and its interactions with the central nervous system. Finally, we state our vision for possible therapeutic uses of compounds based in the components of this hepatic axis.

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