Altered Metabolomics in Bipolar Depression With Gastrointestinal Symptoms

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2022 Jun 10

PMID 35686183

Authors

Xiang-Jie Guo

Yan-Bing Xiong

Yuan Jia

Xiao-Hong Cui

Wen-Ze Wu

Jun-Sheng Tian

Hong Yang

Yan Ren

Affiliations

Soon will be listed here.

Abstract

Objective: Although gastrointestinal (GI) symptoms are very common in patients with bipolar disorder (BD), Few studies have researched the pathomechanism behind these symptoms. In the present study, we aim at elucidate the pathomechanism of GI symptoms in BD through metabolomic analysis.

Method: BD patients were recruited from Shanxi Bethune Hospital that divided into two groups, each group assessed with the 24-item Hamilton Depression Rating Scale (HAMD-24) according to the presence or absence of GI symptoms. Healthy controls were recruited from the medical examination center of the same hospital. Differential metabolites were identified and further analyzed using Metabo Analyst 3.0 to identify associated metabolic pathways.

Results: There were significantly higher HAMD-24 scores in the GI symptoms group than that of non-GI symptoms group ( = 0.007). Based on metabolomic analysis results, we found that the common disturbances metabolic pathway of both two patients groups was ketone body metabolism, and the unique disturbances metabolic pathways of BD with GI symptoms were fatty acid biosynthesis and tyrosine metabolism, and these changes were independent of dietary habits.

Conclusion: BD patients with GI symptoms exhibited disturbances in fatty acid and tyrosine metabolism, perhaps suggesting that the GI symptoms in BD patients are related to disturbances of the gut microbiome. Both groups of patients jointly exhibit disturbances of ketone body metabolism, which may serve as a biomarker for the pathogenesis of BD patients.

Citing Articles

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Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis.

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