Effect of Vitamin D on Paraxonase-1, Total Antioxidant Capacity, and 8-Isoprostan in Children with Attention Deficit Hyperactivity Disorder

Overview

Journal Int J Clin Pract

Publisher Wiley

Specialty General Medicine

Date 2022 Jun 10

PMID 35685610

Authors

Niyaz Mohammadzadeh Honarvar

Mahsa Samadi

Marzieh Seyedi Chimeh

Fatemeh Gholami

Niki Bahrampour

Mahmoud Jalali

Mohammad Effatpanah

Mir Saeid Yekaninejad

Mina Abdolahi

Maryam Chamari

Affiliations

Soon will be listed here.

Abstract

Method: In this double-blind, randomized, placebo-controlled trial, 75 children (aged 6-12) diagnosed with ADHD were randomly assigned into two groups. The supplementation group received vitamin D3 (2000 IU), and the control group received a placebo for 3 months. Blood samples were collected at baseline and after intervention to analyze the 25(OH)D, paraxonase-1 activity (PON-1), Total Antioxidant Capacity (TAC), and 8-isoprostan levels.

Results: A significant rise in circulating 25(OH)D was observed in the vitamin D group versus the placebo group at the end of the study. There was no reduction in 8-isoprostan levels in the vitamin D group compared to the placebo group. Serum paraxonase-1 and TAC concentration decreased in both groups, but these alterations were not statistically significant in the treatment group versus the placebo group at the end of the intervention.

Conclusion: Vitamin D supplementation for 3 months did not have beneficial effects on biomarkers of oxidative stress status. To confirm these findings, further studies on children are suggested.

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