Natural Products in Preventing Tumor Drug Resistance and Related Signaling Pathways

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Jun 10

PMID 35684449

Authors

Chuansheng Yang

Zhikai Mai

Can Liu

Shuanghong Yin

Yantao Cai

Chenglai Xia

Affiliations

Soon will be listed here.

Abstract

Drug resistance is still an obstacle in cancer therapy, leading to the failure of tumor treatment. The emergence of tumor drug resistance has always been a main concern of oncologists. Therefore, overcoming tumor drug resistance and looking for new strategies for tumor treatment is a major focus in the field of tumor research. Natural products serve as effective substances against drug resistance because of their diverse chemical structures and pharmacological effects. We reviewed the signaling pathways involved in the development of tumor drug resistance, including Epidermal growth factor receptor (EGFR), Renin-angiotensin system (Ras), Phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), Wnt, Notch, Transforming growth factor-beta (TGF-β), and their specific signaling pathway inhibitors derived from natural products. This can provide new ideas for the prevention of drug resistance in cancer therapy.

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References

Qi J, Yu J, Li Y, Luo J, Zhang C, Ou S . Alternating consumption of β-glucan and quercetin reduces mortality in mice with colorectal cancer. Food Sci Nutr. 2019; 7(10):3273-3285. PMC: 6804767. DOI: 10.1002/fsn3.1187. View

Wan Mohd Tajuddin W, Lajis N, Abas F, Othman I, Naidu R . Mechanistic Understanding of Curcumin's Therapeutic Effects in Lung Cancer. Nutrients. 2019; 11(12). PMC: 6950067. DOI: 10.3390/nu11122989. View

McMahon C, Ferng T, Canaani J, Wang E, Morrissette J, Eastburn D . Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia. Cancer Discov. 2019; 9(8):1050-1063. DOI: 10.1158/2159-8290.CD-18-1453. View

Erdogan S, Turkekul K, Dibirdik I, Doganlar O, Doganlar Z, Bilir A . Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway. Biomed Pharmacother. 2018; 107:793-805. DOI: 10.1016/j.biopha.2018.08.061. View

Li Y, Yu C, Deng W . Roles and mechanisms of adipokines in drug resistance of tumor cells. Eur J Pharmacol. 2021; 899:174019. DOI: 10.1016/j.ejphar.2021.174019. View

Wang L, Sui M, Wang X . miR‑338‑3p suppresses the malignancy of T‑cell lymphoblastic lymphoma by downregulating HOXA3. Mol Med Rep. 2019; 20(3):2127-2134. PMC: 6691266. DOI: 10.3892/mmr.2019.10451. View

Huang H, Wang Q, Du T, Lin C, Lai Y, Zhu D . Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B. Prostate. 2018; 78(5):327-335. DOI: 10.1002/pros.23469. View

Wu J, Wang L, Du X, Sun Q, Wang Y, Li M . α-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA‑138 expression. Oncol Rep. 2018; 39(3):1163-1172. DOI: 10.3892/or.2018.6187. View

Lan C, Chen S, Kuo C, Lu C, Yen G . Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells. J Food Drug Anal. 2019; 27(4):887-896. PMC: 9306979. DOI: 10.1016/j.jfda.2019.07.001. View

10.

Erdogan S, Turkekul K . Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation. J Food Biochem. 2020; 44(7):e13253. DOI: 10.1111/jfbc.13253. View

11.

Juan T, Liu K, Kuo C, Yang M, Chu Y, Yang J . Tetrandrine suppresses adhesion, migration and invasion of human colon cancer SW620 cells via inhibition of nuclear factor-κB, matrix metalloproteinase-2 and matrix metalloproteinase-9 signaling pathways. Oncol Lett. 2018; 15(5):7716-7724. PMC: 5921181. DOI: 10.3892/ol.2018.8286. View

12.

Law B, Michelangeli F, Qu Y, Xu S, Han Y, Mok S . Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca-dependent mechanism. Sci Rep. 2019; 9(1):20034. PMC: 6934498. DOI: 10.1038/s41598-019-56675-6. View

13.

Zhang H, Savage S, Schultz A, Bottomly D, White L, Segerdell E . Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Nat Commun. 2019; 10(1):244. PMC: 6335421. DOI: 10.1038/s41467-018-08263-x. View

14.

Manogaran P, Somasundaram B, Viswanadha V . Reversal of cisplatin resistance by neferine/isoliensinine and their combinatorial regimens with cisplatin-induced apoptosis in cisplatin-resistant colon cancer stem cells (CSCs). J Biochem Mol Toxicol. 2021; 36(3):e22967. DOI: 10.1002/jbt.22967. View

15.

Chen Z, Huang C, Ma T, Jiang L, Tang L, Shi T . Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells. Phytomedicine. 2018; 43:37-45. DOI: 10.1016/j.phymed.2018.03.040. View

16.

Ahmadzada T, Kao S, Reid G, Boyer M, Mahar A, Cooper W . An Update on Predictive Biomarkers for Treatment Selection in Non-Small Cell Lung Cancer. J Clin Med. 2018; 7(6). PMC: 6025105. DOI: 10.3390/jcm7060153. View

17.

Gao S, Li X, Ding X, Qi W, Yang Q . Cepharanthine Induces Autophagy, Apoptosis and Cell Cycle Arrest in Breast Cancer Cells. Cell Physiol Biochem. 2017; 41(4):1633-1648. DOI: 10.1159/000471234. View

18.

Han H, Li Y, Qin W, Wang L, Yin H, Su B . miR-199b-3p contributes to acquired resistance to cetuximab in colorectal cancer by targeting CRIM1 via Wnt/β-catenin signaling. Cancer Cell Int. 2022; 22(1):42. PMC: 8796585. DOI: 10.1186/s12935-022-02460-x. View

19.

Zhang H, Jiang L, Zhong S, Li J, Sun D, Hou J . The role of long non-coding RNAs in drug resistance of cancer. Clin Genet. 2020; 99(1):84-92. DOI: 10.1111/cge.13800. View

20.

Yamaoka T, Kusumoto S, Ando K, Ohba M, Ohmori T . Receptor Tyrosine Kinase-Targeted Cancer Therapy. Int J Mol Sci. 2018; 19(11). PMC: 6274851. DOI: 10.3390/ijms19113491. View