Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Jun 10

PMID 35684414

Authors

Gulim K Mukusheva

Aigerym R Zhasymbekova

Roza B Seidakhmetova

Oralgazy A Nurkenov

Ekaterina A Akishina

Sergey K Petkevich

Evgenij A Dikusar

Vladimir I Potkin

Affiliations

Soon will be listed here.

Abstract

An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds , , and with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid.

Citing Articles

Synthesis and Biological Activity of -acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments.

Mukusheva G, Zhasymbekova A, Zhumagalieva Z, Seidakhmetova R, Nurkenov O, Akishina E Molecules. 2022; 27(21).

PMID: 36364219 PMC: 9656753. DOI: 10.3390/molecules27217387.

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