Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Jun 10

PMID 35684377

Authors

Zahira Kibou

Nadia Aissaoui

Ismail Daoud

Julio A Seijas

Maria Pilar Vazquez-Tato

Nihel Klouche Khelil

Noureddine Choukchou-Braham

Affiliations

Soon will be listed here.

Abstract

Background: This synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using enaminones as key precursors under solvent-free conditions.

Methods: A range of spectroscopic techniques was used to determine and confirm the chemical structures (FTIR, H NMR, C NMR). The antimicrobial potency of synthesized compounds (-) was tested using disk diffusion assays, and the Minimum Inhibitory Concentration (MIC) for the active compounds was determined against a panel of microorganisms, including Gram-positive and Gram-negative bacteria and yeasts. Moreover, a docking analysis was conducted by Molecular Operating Environment (MOE) software to provide supplementary information about the potential, as well as an ADME-T prediction to describe the pharmacokinetic properties of the best compound and its toxicity.

Results: The results of the antimicrobial activity indicated that compound showed the highest activity against Gram-positive bacteria, particularly and whose MIC values were 0.039 ± 0.000 µg·mL. The results of the theoretical study of compound were in line with the experimental data and exhibited excellent antibacterial potential.

Conclusions: On the basis of the obtained results, compound can be used as an antibacterial agent model with high antibacterial potency.

Citing Articles

Cracking the code: the clinical and molecular impact of aminopyridines; a review (2019-2024).

Khalid T, Malik A, Rasool N, Kanwal A, Nawaz H, Almas I RSC Adv. 2025; 15(1):688-711.

PMID: 39781020 PMC: 11708541. DOI: 10.1039/d4ra07438f.

Design, Synthesis, Molecular Docking, and ADME-Tox Investigations of Imidazo[1,2-a]Pyrimidines Derivatives as Antimicrobial Agents.

Benzenine D, Daoud I, Aissaoui N, Kibou Z, Seijas J, Vazquez-Tato M Molecules. 2024; 29(21).

PMID: 39519699 PMC: 11547262. DOI: 10.3390/molecules29215058.

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