The Effect of Coenzyme Q10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type II Diabetic Patients: A Randomized Controlled Clinical Trial

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Jun 10

PMID 35683447

Authors

Mostafa Ghanem

Lamia Heikal

Hagar Abdel Fattah

Adham El Ashwah

Riham Fliefel

Affiliations

Soon will be listed here.

Abstract

Background: The healing of an extraction socket leads to alveolar ridge resorption that can hinder future implant placement and further rehabilitation with special concerns in diabetes mellitus. Coenzyme Q10 (CoQ10) has been developed as a new material for alveolar socket augmentation. The aim of this study was to investigate the effect of CoQ10 hydrogel on bone regeneration after extraction of mandibular teeth in Type II diabetic patients.

Methods: This trial was registered under the number NCT05122299 and included eighteen patients. The hydrogel was first prepared and characterized. After tooth extraction, the hydrogel was placed in the extraction sockets. Bone formation was evaluated three months after tooth extraction.

Results: The bone density was significantly higher in the CoQ10 group than the other two groups measured on cone beam computed tomography (CBCT). The relative gene expression of Runt-related transcription factor 2 (RUNX2) and Osteopontin (OPN) showed significant increase in the presence of CoQ10. Histomorphometry revealed significantly less fibrous tissue in the CoQ10 group in comparison to the control or collagen group.

Conclusion: The local application of CoQ10 after tooth extraction provided a simple, inexpensive, yet effective treatment facilitating bone formation and healing in the extraction sockets of diabetic patients.

Citing Articles

Role of oxidative stress in impaired type II diabetic bone repair: scope for antioxidant therapy intervention?.

Li P, Alenazi K, Dally J, Woods E, Waddington R, Moseley R Front Dent Med. 2025; 5:1464009.

PMID: 39917650 PMC: 11797775. DOI: 10.3389/fdmed.2024.1464009.

Effect of Coenzyme Q10 on early wound healing after recession coverage surgery with the modified coronally advanced tunnel technique and a connective tissue graft: A 6-month, triple-blinded, randomized, placebo-controlled pilot trial.

Stahli A, De Ry S, Roccuzzo A, Imber J, Sculean A Clin Oral Investig. 2024; 28(8):424.

PMID: 38990401 PMC: 11239743. DOI: 10.1007/s00784-024-05790-4.

Smart Hydrogels for Bone Reconstruction via Modulating the Microenvironment.

Chen W, Zhang H, Zhou Q, Zhou F, Zhang Q, Su J Research (Wash D C). 2023; 6:0089.

PMID: 36996343 PMC: 10042443. DOI: 10.34133/research.0089.

References

Bhagavan H, Chopra R . Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006; 40(5):445-53. DOI: 10.1080/10715760600617843. View

Lee J, Yun J, Kim J, Koo K, Seol Y, Lee Y . Retrospective study of alveolar ridge preservation compared with no alveolar ridge preservation in periodontally compromised extraction sockets. Int J Implant Dent. 2021; 7(1):23. PMC: 7994480. DOI: 10.1186/s40729-021-00305-2. View

Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X . Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018; 16(1):29. PMC: 5870379. DOI: 10.1186/s12958-018-0343-0. View

Saito H, Couso-Queiruga E, Shiau H, Stuhr S, Prasad H, Allareddy T . Evaluation of poly lactic-co-glycolic acid-coated β-tricalcium phosphate for alveolar ridge preservation: A multicenter randomized controlled trial. J Periodontol. 2020; 92(4):524-535. DOI: 10.1002/JPER.20-0360. View

Jambhekar S, Kernen F, Bidra A . Clinical and histologic outcomes of socket grafting after flapless tooth extraction: a systematic review of randomized controlled clinical trials. J Prosthet Dent. 2015; 113(5):371-82. DOI: 10.1016/j.prosdent.2014.12.009. View

Anitua E, Murias-Freijo A, Alkhraisat M, Orive G . Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: a randomized controlled clinical trial. Clin Oral Investig. 2014; 19(3):589-600. DOI: 10.1007/s00784-014-1278-2. View

Gadicherla S, Smriti K, Roy S, Pentapati K, Rajan J, Walia A . Comparison of Extraction Socket Healing in Non-Diabetic, Prediabetic, and Type 2 Diabetic Patients. Clin Cosmet Investig Dent. 2020; 12:291-296. PMC: 7381775. DOI: 10.2147/CCIDE.S264196. View

Alavi S, Akhlaghi S, Dadashzadeh S, Haeri A . Green Formulation of Triglyceride/Phospholipid-Based Nanocarriers as a Novel Vehicle for Oral Coenzyme Q10 Delivery. J Food Sci. 2019; 84(9):2572-2583. DOI: 10.1111/1750-3841.14763. View

Rueden C, Schindelin J, Hiner M, DeZonia B, Walter A, Arena E . ImageJ2: ImageJ for the next generation of scientific image data. BMC Bioinformatics. 2017; 18(1):529. PMC: 5708080. DOI: 10.1186/s12859-017-1934-z. View

10.

Jo S, Kim S, Cho T, Shin E, Hwang S, Noh I . Effects of recombinant human bone morphogenic protein-2 and human bone marrow-derived stromal cells on in vivo bone regeneration of chitosan-poly(ethylene oxide) hydrogel. J Biomed Mater Res A. 2012; 101(3):892-901. DOI: 10.1002/jbm.a.34354. View

11.

Flowers N, Hartley L, Todkill D, Stranges S, Rees K . Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2014; (12):CD010405. PMC: 9759150. DOI: 10.1002/14651858.CD010405.pub2. View

12.

Kotze M, Butow K, Kotze H . A radiological method to evaluate alveolar bone regeneration in the Chacma baboon (Papio ursinus). SADJ. 2012; 67(5):210-4. View

13.

Khuankaew C, Apaijai N, Sawaddiruk P, Jaiwongkam T, Kerdphoo S, Pongsiriwet S . Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia. Free Radic Res. 2018; 52(4):415-425. DOI: 10.1080/10715762.2018.1438608. View

14.

Shen Q, Pierce J . Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus. Healthcare (Basel). 2016; 3(2):296-309. PMC: 4939545. DOI: 10.3390/healthcare3020296. View

15.

Elfana A, El-Kholy S, Saleh H, Fawzy El-Sayed K . Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial. Clin Oral Implants Res. 2021; 32(5):539-548. DOI: 10.1111/clr.13722. View

16.

Florou P, Anagnostis P, Theocharis P, Chourdakis M, Goulis D . Does coenzyme Q supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials. J Assist Reprod Genet. 2020; 37(10):2377-2387. PMC: 7550497. DOI: 10.1007/s10815-020-01906-3. View

17.

Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T, Kasitanon N, Jaiwongkam T . Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients reducing brain activity and mitochondrial dysfunction. Free Radic Res. 2019; 53(8):901-909. DOI: 10.1080/10715762.2019.1645955. View

18.

Ustaoglu G, Goller Bulut D, Gumus K . Evaluation of different platelet-rich concentrates effects on early soft tissue healing and socket preservation after tooth extraction. J Stomatol Oral Maxillofac Surg. 2019; 121(5):539-544. DOI: 10.1016/j.jormas.2019.09.005. View

19.

Zhang S, Song S, Wang S, Duan Y, Zhu W, Song Y . Type 2 diabetes affects postextraction socket healing and influences first-stage implant surgery: A study based on clinical and animal evidence. Clin Implant Dent Relat Res. 2019; 21(3):436-445. DOI: 10.1111/cid.12780. View

20.

Manthena S, Ramoji Rao M, Penubolu L, Putcha M, Harsha A . Effectiveness of CoQ10 Oral Supplements as an Adjunct to Scaling and Root Planing in Improving Periodontal Health. J Clin Diagn Res. 2015; 9(8):ZC26-8. PMC: 4576635. DOI: 10.7860/JCDR/2015/13486.6291. View