Age-Related Changes in the Fibroblastic Differon of the Dermis: Role in Skin Aging

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jun 10

PMID 35682813

Authors

Alla Zorina

Vadim Zorin

Dmitry Kudlay

Pavel Kopnin

Affiliations

Soon will be listed here.

Abstract

Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and function. The processes developing in the skin during aging are based on fundamental molecular mechanisms associated with fibroblasts, the main cellular population of the dermis. It has been revealed that the amount of fibroblasts decreases markedly with age and their functional activity is also reduced. This inevitably leads to a decrease in the regenerative abilities of the skin and the progression of its aging. In this review we consider the mechanisms underlying these processes, mainly the changes observed with age in the stem/progenitor cells that constitute the fibroblastic differon of the dermis and form their microenvironment (niches). These changes lead to the depletion of stem cells, which, in turn, leads to a decrease in the number of differentiated (mature) dermal fibroblasts responsible for the production of the dermal extracellular matrix and its remodeling. We also describe in detail DNA damages, their cellular and systemic consequences, molecular mechanisms of DNA damage response, and also the role of fibroblast senescence in skin aging.

Citing Articles

Protective effects of a novel FS-Collagen hydrolysates against UV- and d-galactose-induced skin aging.

Zhang Y, Huang G, Zhang Z, Xu Y, Ren J, Sun W Food Sci Biotechnol. 2025; 34(1):257-267.

PMID: 39758722 PMC: 11695533. DOI: 10.1007/s10068-024-01660-7.

An orchestra of machine learning methods reveals landmarks in single-cell data exemplified with aging fibroblasts.

Rasbach L, Caliskan A, Saderi F, Dandekar T, Breitenbach T PLoS One. 2024; 19(4):e0302045.

PMID: 38630692 PMC: 11023401. DOI: 10.1371/journal.pone.0302045.

Unripe Fresh Fruit Extract Protects against Methylglyoxal-Mediated Aging in Human Dermal Skin Fibroblasts.

Wattanapitayakul S, Jarisarapurin W, Kunchana K, Setthawong V, Chularojmontri L Prev Nutr Food Sci. 2023; 28(3):235-245.

PMID: 37842248 PMC: 10567595. DOI: 10.3746/pnf.2023.28.3.235.

Ameliorative effect of black tea extract on the skin of D-galactose-induced aging mice.

Zheng X, Deng W, Wang X, Wu Z, Li C, Zhang X Front Nutr. 2023; 10:1275199.

PMID: 37781120 PMC: 10540639. DOI: 10.3389/fnut.2023.1275199.

Dermal Fibroblasts as the Main Target for Skin Anti-Age Correction Using a Combination of Regenerative Medicine Methods.

Zorina A, Zorin V, Isaev A, Kudlay D, Vasileva M, Kopnin P Curr Issues Mol Biol. 2023; 45(5):3829-3847.

PMID: 37232716 PMC: 10217460. DOI: 10.3390/cimb45050247.

References

Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L . MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015; 17(8):1049-61. PMC: 4691706. DOI: 10.1038/ncb3195. View

Jackson S, Bartek J . The DNA-damage response in human biology and disease. Nature. 2009; 461(7267):1071-8. PMC: 2906700. DOI: 10.1038/nature08467. View

Moehle E, Shen K, Dillin A . Mitochondrial proteostasis in the context of cellular and organismal health and aging. J Biol Chem. 2018; 294(14):5396-5407. PMC: 6462515. DOI: 10.1074/jbc.TM117.000893. View

Gunin A, Petrov V, Golubtzova N, Vasilieva O, Kornilova N . Age-related changes in angiogenesis in human dermis. Exp Gerontol. 2014; 55:143-51. DOI: 10.1016/j.exger.2014.04.010. View

Sun L, Yu R, Dang W . Chromatin Architectural Changes during Cellular Senescence and Aging. Genes (Basel). 2018; 9(4). PMC: 5924553. DOI: 10.3390/genes9040211. View

Sorrell J, Caplan A . Fibroblasts-a diverse population at the center of it all. Int Rev Cell Mol Biol. 2009; 276:161-214. DOI: 10.1016/S1937-6448(09)76004-6. View

Ho C, Dreesen O . Faces of cellular senescence in skin aging. Mech Ageing Dev. 2021; 198:111525. DOI: 10.1016/j.mad.2021.111525. View

Boyman L, Karbowski M, Lederer W . Regulation of Mitochondrial ATP Production: Ca Signaling and Quality Control. Trends Mol Med. 2019; 26(1):21-39. PMC: 7921598. DOI: 10.1016/j.molmed.2019.10.007. View

Madabhushi R, Pan L, Tsai L . DNA damage and its links to neurodegeneration. Neuron. 2014; 83(2):266-282. PMC: 5564444. DOI: 10.1016/j.neuron.2014.06.034. View

10.

Chen D, Kerr C . The Epigenetics of Stem Cell Aging Comes of Age. Trends Cell Biol. 2019; 29(7):563-568. PMC: 7144731. DOI: 10.1016/j.tcb.2019.03.006. View

11.

Borghesan M, Fafian-Labora J, Eleftheriadou O, Carpintero-Fernandez P, Paez-Ribes M, Vizcay-Barrena G . Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep. 2019; 27(13):3956-3971.e6. PMC: 6613042. DOI: 10.1016/j.celrep.2019.05.095. View

12.

Coppe J, Desprez P, Krtolica A, Campisi J . The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118. PMC: 4166495. DOI: 10.1146/annurev-pathol-121808-102144. View

13.

Toutfaire M, Bauwens E, Debacq-Chainiaux F . The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies. Biochem Pharmacol. 2017; 142:1-12. DOI: 10.1016/j.bcp.2017.04.011. View

14.

dAdda di Fagagna F . Living on a break: cellular senescence as a DNA-damage response. Nat Rev Cancer. 2008; 8(7):512-22. DOI: 10.1038/nrc2440. View

15.

Gorgoulis V, Adams P, Alimonti A, Bennett D, Bischof O, Bishop C . Cellular Senescence: Defining a Path Forward. Cell. 2019; 179(4):813-827. DOI: 10.1016/j.cell.2019.10.005. View

16.

Velarde M, Demaria M . Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review. Gerontology. 2016; 62(5):513-8. DOI: 10.1159/000444877. View

17.

Niedernhofer L, Gurkar A, Wang Y, Vijg J, Hoeijmakers J, Robbins P . Nuclear Genomic Instability and Aging. Annu Rev Biochem. 2018; 87:295-322. DOI: 10.1146/annurev-biochem-062917-012239. View

18.

Salminen A, Kaarniranta K, Kauppinen A . Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY). 2012; 4(3):166-75. PMC: 3348477. DOI: 10.18632/aging.100444. View

19.

Morrison S, Spradling A . Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell. 2008; 132(4):598-611. PMC: 4505728. DOI: 10.1016/j.cell.2008.01.038. View

20.

Price F, von Maltzahn J, Bentzinger C, Dumont N, Yin H, Chang N . Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Nat Med. 2014; 20(10):1174-81. PMC: 4191983. DOI: 10.1038/nm.3655. View