Special Issue Editorial: "Infections, Inflammation and Neurodegeneration in Alzheimer Disease" Infections, Neuronal Senescence, and Dementia

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jun 10

PMID 35682542

Authors

Federico Licastro

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is a complex chronic disease of the brain characterized by several neurodegenerative mechanisms and is responsible for most dementia cases in the elderly. Declining immunity during ageing is often associated with peripheral chronic inflammation, and chronic neuroinflammation is a constant component of AD brain pathology. In the Special Issue published in 2021 eight papers were collected regarding different aspects of neurodegeneration associated with AD. Five papers presented and discussed infectious agents involved in brain AD pathology and three discussed data regarding receptors regulation and possible treatment of the disease. Below I will discuss and further elaborate on topics related to infections, inflammation, and neurodegenerative pathways in AD and brain senescence. The topic presented here may contribute to early intervention protocols for preventing or slowing the progression of cognitive deterioration in the elderly.

Citing Articles

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Serafini S, Ferretti G, Monterosso P, Angiolillo A, di Costanzo A, Matrone C Antioxidants (Basel). 2024; 13(2).

PMID: 38397814 PMC: 10886257. DOI: 10.3390/antiox13020216.

Sepsis exacerbates Alzheimer's disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden.

Giridharan V, Catumbela C, Catalao C, Lee J, Ganesh B, Petronilho F Mol Psychiatry. 2023; 28(10):4463-4473.

PMID: 37452088 PMC: 10926876. DOI: 10.1038/s41380-023-02172-2.

References

Chen N, Partridge A, Sell C, Torres C, Martin-Garcia J . Fate of microglia during HIV-1 infection: From activation to senescence?. Glia. 2016; 65(3):431-446. PMC: 5263094. DOI: 10.1002/glia.23081. View

Heath J, Grant M . The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence. Cells. 2020; 9(3). PMC: 7140628. DOI: 10.3390/cells9030766. View

Tawfik A, Elsherbiny N, Zaidi Y, Rajpurohit P . Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation. Int J Mol Sci. 2021; 22(12). PMC: 8230490. DOI: 10.3390/ijms22126259. View

Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P . Virus-induced senescence is a driver and therapeutic target in COVID-19. Nature. 2021; 599(7884):283-289. DOI: 10.1038/s41586-021-03995-1. View

Kang X, Li C, Xie X, Zhan K, Yang S, Tang Y . Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1. Int J Med Sci. 2020; 17(3):310-319. PMC: 7053352. DOI: 10.7150/ijms.38602. View

Beswick M, Pachnio A, Lauder S, Sweet C, Moss P . Antiviral therapy can reverse the development of immune senescence in elderly mice with latent cytomegalovirus infection. J Virol. 2012; 87(2):779-89. PMC: 3554082. DOI: 10.1128/JVI.02427-12. View

Kirkland J, Tchkonia T . Senolytic drugs: from discovery to translation. J Intern Med. 2020; 288(5):518-536. PMC: 7405395. DOI: 10.1111/joim.13141. View

Napoletani G, Protto V, Marcocci M, Nencioni L, Palamara A, De Chiara G . Recurrent Herpes Simplex Virus Type 1 (HSV-1) Infection Modulates Neuronal Aging Marks in In Vitro and In Vivo Models. Int J Mol Sci. 2021; 22(12). PMC: 8230621. DOI: 10.3390/ijms22126279. View

Saez-Atienzar S, Masliah E . Cellular senescence and Alzheimer disease: the egg and the chicken scenario. Nat Rev Neurosci. 2020; 21(8):433-444. DOI: 10.1038/s41583-020-0325-z. View

10.

Chiricosta L, Gugliandolo A, Mazzon E . SARS-CoV-2 Exacerbates Beta-Amyloid Neurotoxicity, Inflammation and Oxidative Stress in Alzheimer's Disease Patients. Int J Mol Sci. 2021; 22(24). PMC: 8705864. DOI: 10.3390/ijms222413603. View

11.

Porcellini E, Carbone I, Ianni M, Licastro F . Alzheimer's disease gene signature says: beware of brain viral infections. Immun Ageing. 2010; 7:16. PMC: 3019140. DOI: 10.1186/1742-4933-7-16. View

12.

Humphreys D, ElGhazaly M, Frisan T . Senescence and Host-Pathogen Interactions. Cells. 2020; 9(7). PMC: 7409240. DOI: 10.3390/cells9071747. View

13.

Antony J, van Marle G, Opii W, Butterfield D, Mallet F, Yong V . Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nat Neurosci. 2004; 7(10):1088-95. DOI: 10.1038/nn1319. View

14.

Romagnoli M, Porcellini E, Carbone I, Veerhuis R, Licastro F . Impaired Innate Immunity Mechanisms in the Brain of Alzheimer's Disease. Int J Mol Sci. 2020; 21(3). PMC: 7038145. DOI: 10.3390/ijms21031126. View

15.

Grandi N, Tramontano E . Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses. Front Immunol. 2018; 9:2039. PMC: 6139349. DOI: 10.3389/fimmu.2018.02039. View

16.

Belshaw R, Pereira V, Katzourakis A, Talbot G, Paces J, Burt A . Long-term reinfection of the human genome by endogenous retroviruses. Proc Natl Acad Sci U S A. 2004; 101(14):4894-9. PMC: 387345. DOI: 10.1073/pnas.0307800101. View

17.

Soscia S, Kirby J, Washicosky K, Tucker S, Ingelsson M, Hyman B . The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One. 2010; 5(3):e9505. PMC: 2831066. DOI: 10.1371/journal.pone.0009505. View

18.

Zhu M, Liu B, Shi L, Wang X, Wang Y . mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine. J Cell Mol Med. 2020; 24(20):12082-12093. PMC: 7579718. DOI: 10.1111/jcmm.15841. View

19.

Licastro F, Porcellini E . Activation of Endogenous Retrovirus, Brain Infections and Environmental Insults in Neurodegeneration and Alzheimer's Disease. Int J Mol Sci. 2021; 22(14). PMC: 8303979. DOI: 10.3390/ijms22147263. View

20.

Grossmann K . Alzheimer's Disease-Rationales for Potential Treatment with the Thrombin Inhibitor Dabigatran. Int J Mol Sci. 2021; 22(9). PMC: 8125318. DOI: 10.3390/ijms22094805. View