Genome-Wide Selective Analysis of Boer Goat to Investigate the Dynamic Heredity Evolution Under Different Stages

Overview

Journal Animals (Basel)

Date 2022 Jun 10

PMID 35681821

Authors

Ying Yuan

Weiyi Zhang

Chengli Liu

Yongmeng He

Haoyuan Zhang

Lu Xu

Baigao Yang

Yongju Zhao

Yuehui Ma

Mingxing Chu

Zhongquan Zhao

Yongfu Huang

Yanguo Han

Yan Zeng

Hangxing Ren

Gaofu Wang

Guangxin E

Affiliations

Soon will be listed here.

Abstract

Boer goats, as kemp in meat-type goats, are selected and bred from African indigenous goats under a long period of artificial selection. Their advantages in multiple economic traits, particularly their plump growth, have attracted worldwide attention. The current study displayed the genome-wide selection signature analyses of South African indigenous goat (AF), African Boer (BH), and Australian Boer (AS) to investigate the hereditary basis of artificial selection in different stages. Four methods (principal component analysis, nucleotide diversity, linkage disequilibrium decay, and neighbor-joining tree) implied the genomic diversity changes with different artificial selection intensities in Boer goats. In addition, the θπ, F, and XP-CLR methods were used to search for the candidate signatures of positive selection in Boer goats. Consequently, 339 (BH vs. AF) and 295 (AS vs. BH) candidate genes were obtained from SNP data. Especially, 10 genes (e.g., , , , and ) under selection in both groups were identified. Functional annotation analysis revealed that these genes are potentially responsible for reproduction, metabolism, growth, and development. This study used genome-wide sequencing data to identify inheritance by artificial selection. The results of the current study are valuable for future molecular-assisted breeding and genetic improvement of goats.

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