Clinical Value and Molecular Function of Circulating MicroRNAs in Endometrial Cancer Regulation: A Systematic Review

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Jun 10

PMID 35681531

Authors

Joy Bloomfield

Michele Sabbah

Mathieu Castela

Celine Mehats

Catherine Uzan

Geoffroy Canlorbe

Affiliations

Soon will be listed here.

Abstract

This systematic review of literature highlights the different microRNAs circulating in the serum or plasma of endometrial cancer patients and their association with clinical and prognostic characteristics in endometrial cancer. This study also investigates the molecular functions of these circulating microRNAs. According to this systematic review, a total of 33 individual circulating miRs (-9, -15b, -20b-5p, -21, -27a, -29b, -30a-5p, -92a, -99a, -100, -135b, -141, -142-3p, -143-3p, -146a-5p, -150-5p, -151a-5p, -186, -195-5p, -199b, -200a, -203, -204, -205, -222, -223, -301b, -423-3p, -449, -484, -887-5p, -1228, and -1290) and 6 different panels of miRs ("miR-222/miR-223/miR-186/miR-204", "miR-142-3p/miR-146a-5p/miR-151a-5p", "miR-143-3p/miR-195-5p/miR-20b-5p/miR-204-5p/miR-423-3p/miR-484", "mir-9/miR-1229", "miR-9/miR-92a", and "miR-99a/miR-199b") had a significant expression variation in EC patients compared to healthy patients. Also, seven individual circulating miRs (-9, -21, -27a, -29b, -99a, -142-3p, and -449a) had a significant expression variation according to EC prognostic factors such as the histological type and grade, tumor size, FIGO stage, lymph node involvement, and survival rates. One panel of circulating miRs ("-200b/-200c/-203/-449a") had a significant expression variation according to EC myometrial invasion. Further studies are needed to better understand their function and circulation.

Citing Articles

Plasma miRNAs in polycystic ovary syndrome drive endometrial cancer progression: insights into molecular pathways and therapeutic targets.

Lai X, Wu L, Lin P, You L, Ye J Discov Oncol. 2025; 16(1):133.

PMID: 39920371 PMC: 11806182. DOI: 10.1007/s12672-025-01861-4.

Advancements in Minimally Invasive Techniques and Biomarkers for the Early Detection of Endometrial Cancer: A Comprehensive Review of Novel Diagnostic Approaches and Clinical Implications.

Asaturova A, Zaretsky A, Rogozhina A, Tregubova A, Badlaeva A J Clin Med. 2025; 13(24.

PMID: 39768459 PMC: 11728107. DOI: 10.3390/jcm13247538.

Mesonephric-like Adenocarcinoma of the Uterine Corpus: Genomic and Immunohistochemical Profiling with Comprehensive Clinicopathological Analysis of 17 Consecutive Cases from a Single Institution.

Koh H, Park E, Kim H Biomedicines. 2023; 11(8).

PMID: 37626765 PMC: 10452884. DOI: 10.3390/biomedicines11082269.

Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer-Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects.

Piergentili R, Gullo G, Basile G, Gulia C, Porrello A, Cucinella G Int J Mol Sci. 2023; 24(14).

PMID: 37511115 PMC: 10379073. DOI: 10.3390/ijms241411356.

The influence of selected microRNAs on the expression profile of genes and proteins related to the tumor necrosis factor-alpha signaling pathways in endometrioid endometrial cancer.

Zmarzly N, Januszyk S, Mieszczanski P, Czarniecka J, Bednarska-Czerwinska A, Boron D J Cancer Res Clin Oncol. 2023; 149(12):9679-9689.

PMID: 37233761 PMC: 10423110. DOI: 10.1007/s00432-023-04863-3.

References

Gao Y, Dai M, Liu H, He W, Lin S, Yuan T . Diagnostic value of circulating miR-21: An update meta-analysis in various cancers and validation in endometrial cancer. Oncotarget. 2016; 7(42):68894-68908. PMC: 5356598. DOI: 10.18632/oncotarget.12028. View

Hoshino I . The usefulness of microRNA in urine and saliva as a biomarker of gastroenterological cancer. Int J Clin Oncol. 2021; 26(8):1431-1440. DOI: 10.1007/s10147-021-01911-1. View

Xiong W, Han N, Ping G, Zheng P, Feng H, Qin L . microRNA-9 functions as a tumor suppressor in colorectal cancer by targeting CXCR4. Int J Clin Exp Pathol. 2020; 11(2):526-536. PMC: 6958006. View

Rizner T . Discovery of biomarkers for endometrial cancer: current status and prospects. Expert Rev Mol Diagn. 2016; 16(12):1315-1336. DOI: 10.1080/14737159.2016.1258302. View

Klicka K, Grzywa T, Klinke A, Mielniczuk A, Wlodarski P . The Role of miRNAs in the Regulation of Endometrial Cancer Invasiveness and Metastasis-A Systematic Review. Cancers (Basel). 2021; 13(14). PMC: 8304659. DOI: 10.3390/cancers13143393. View

Song Q, An Q, Niu B, Lu X, Zhang N, Cao X . Role of miR-221/222 in Tumor Development and the Underlying Mechanism. J Oncol. 2020; 2019:7252013. PMC: 6942871. DOI: 10.1155/2019/7252013. View

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

Turchinovich A, Weiz L, Langheinz A, Burwinkel B . Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011; 39(16):7223-33. PMC: 3167594. DOI: 10.1093/nar/gkr254. View

Favier A, Rocher G, Larsen A, Delangle R, Uzan C, Sabbah M . MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review. Cancers (Basel). 2021; 13(5). PMC: 7961497. DOI: 10.3390/cancers13051137. View

10.

Yanokura M, Banno K, Adachi M, Aoki D, Abe K . Genome-wide DNA methylation sequencing reveals miR-663a is a novel epimutation candidate in CIMP-high endometrial cancer. Int J Oncol. 2017; 50(6):1934-1946. PMC: 5435325. DOI: 10.3892/ijo.2017.3966. View

11.

Benati M, Montagnana M, Danese E, Paviati E, Giudici S, Franchi M . Evaluation of mir-203 Expression Levels and DNA Promoter Methylation Status in Serum of Patients with Endometrial Cancer. Clin Lab. 2017; 63(10):1675-1681. DOI: 10.7754/Clin.Lab.2017.170421. View

12.

Daix M, Angeles M, Migliorelli F, Kakkos A, Gomez C, Delbecque K . Concordance between preoperative ESMO-ESGO-ESTRO risk classification and final histology in early-stage endometrial cancer. J Gynecol Oncol. 2021; 32(4):e48. PMC: 8192240. DOI: 10.3802/jgo.2021.32.e48. View

13.

Kong J, He X, Wang Y, Li J . Effect of microRNA-29b on proliferation, migration, and invasion of endometrial cancer cells. J Int Med Res. 2019; 47(8):3803-3817. PMC: 6726808. DOI: 10.1177/0300060519844403. View

14.

Imboden S, Nastic D, Ghaderi M, Rydberg F, Siegenthaler F, Mueller M . Implementation of the 2021 molecular ESGO/ESTRO/ESP risk groups in endometrial cancer. Gynecol Oncol. 2021; 162(2):394-400. DOI: 10.1016/j.ygyno.2021.05.026. View

15.

Liu X, Pan B, Sun L, Chen X, Zeng K, Hu X . Circulating Exosomal miR-27a and miR-130a Act as Novel Diagnostic and Prognostic Biomarkers of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2018; 27(7):746-754. DOI: 10.1158/1055-9965.EPI-18-0067. View

16.

Zhang H, Li B, Zhao H, Chang J . The expression and clinical significance of serum miR-205 for breast cancer and its role in detection of human cancers. Int J Clin Exp Med. 2015; 8(2):3034-43. PMC: 4402927. View

17.

Torres A, Torres K, Pesci A, Ceccaroni M, Paszkowski T, Cassandrini P . Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma. BMC Cancer. 2012; 12:369. PMC: 3495850. DOI: 10.1186/1471-2407-12-369. View

18.

Donkers H, Hirschfeld M, Weiss D, Erbes T, Jager M, Pijnenborg J . Detection of microRNA in urine to identify patients with endometrial cancer: a feasibility study. Int J Gynecol Cancer. 2021; 31(6):868-874. DOI: 10.1136/ijgc-2021-002494. View

19.

Huan T, Chen G, Liu C, Bhattacharya A, Rong J, Chen B . Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits. Aging Cell. 2017; 17(1). PMC: 5770777. DOI: 10.1111/acel.12687. View

20.

Ma L, Li Z, Li W, Ai J, Chen X . MicroRNA-142-3p suppresses endometriosis by regulating KLF9-mediated autophagy and . RNA Biol. 2019; 16(12):1733-1748. PMC: 6844572. DOI: 10.1080/15476286.2019.1657352. View