Something Fishy About Siamese Fighting Fish () Sex: Polygenic Sex Determination or a Newly Emerged Sex-Determining Region?

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Jun 10

PMID 35681459

Authors

Thitipong Panthum

Kitipong Jaisamut

Worapong Singchat

Syed Farhan Ahmad

Lalida Kongkaew

Wongsathit Wongloet

Sahabhop Dokkaew

Ekaphan Kraichak

Narongrit Muangmai

Prateep Duengkae

Kornsorn Srikulnath

Affiliations

Soon will be listed here.

Abstract

Fishes provide a unique and intriguing model system for studying the genomic origin and evolutionary mechanisms underlying sex determination and high sex-chromosome turnover. In this study, the mode of sex determination was investigated in Siamese fighting fish, a species of commercial importance. Genome-wide SNP analyses were performed on 75 individuals (40 males and 35 females) across commercial populations to determine candidate sex-specific/sex-linked loci. In total, 73 male-specific loci were identified and mapped to a 5.6 kb region on chromosome 9, suggesting a putative male-determining region (pMDR) containing localized and functional sex developmental genes. Repeat annotations of the pMDR revealed an abundance of transposable elements, particularly Ty3/Gypsy and novel repeats. Remarkably, two out of the 73 male-specific loci were located on chromosomes 7 and 19, implying the existence of polygenic sex determination. Besides male-specific loci, five female-specific loci on chromosome 9 were also observed in certain populations, indicating the possibility of a female-determining region and the polygenic nature of sex determination. An alternative explanation is that male-specific loci derived from other chromosomes or female-specific loci in Siamese fighting fish recently emerged as new sex-determining loci during domestication and repeated hybridization.

Citing Articles

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Master-Key Regulators of Sex Determination in Fish and Other Vertebrates-A Review.

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Polygenic sex determination in vertebrates - is there any such thing?.

Schartl M, Georges A, Marshall Graves J Trends Genet. 2023; 39(4):242-250.

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