Ventilator-associated Pneumonia Prevention in the Intensive Care Unit Using Postpyloric Tube Feeding in China (VIP Study): Study Protocol for a Randomized Controlled Trial

Overview

Journal Trials

Publisher Biomed Central

Specialties General Medicine
Pharmacology

Date 2022 Jun 10

PMID 35681155

Authors

Linhui Hu

Kaiyi Peng

Xiangwei Huang

Zheng Wang

Quanzhong Wu

Yumei Xiao

Yating Hou

Yuemei He

Xinjuan Zhou

Chunbo Chen

Affiliations

Soon will be listed here.

Abstract

Background: Ventilator-associated pneumonia is a challenge in critical care and is associated with high mortality and morbidity. Although some consensuses on preventing ventilator-associated pneumonia are reached, it is still somewhat controversial. Meta-analysis has shown that postpyloric tube feeding may reduce the incidences of ventilator-associated pneumonia, which still desires high-quality evidence. This trial aims to evaluate the efficacy and safety profiles of postpyloric tube feeding versus gastric tube feeding.

Methods/design: In this multicenter, open-label, randomized controlled trial, we will recruit 924 subjects expected to receive mechanical ventilation for no less than 48 h. Subjects on mechanical ventilation will be randomized (1:1) to receive postpyloric or gastric tube feeding and routine preventive measures simultaneously. The primary outcome is the proportion of patients with at least one ventilator-associated pneumonia episode. Adverse events and serious adverse events will be observed closely.

Discussion: The VIP study is a large-sample-sized, multicenter, open-label, randomized, parallel-group, controlled trial of postpyloric tube feeding in China and is well-designed based on previous studies. The results of this trial may help to provide evidence-based recommendations for the prevention of ventilator-associated pneumonia.

Trial Registration: Chictr.org.cn ChiCTR2100051593 . Registered on 28 September 2021.

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