Cellular Crosstalk in the Vascular Wall Microenvironment: The Role of Exosomes in Vascular Calcification

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2022 Jun 9

PMID 35677687

Authors

Yun-Yun Wu

Su-Kang Shan

Xiao Lin

Feng Xu

Jia-Yu Zhong

Feng Wu

Jia-Yue Duan

Bei Guo

Fu-Xing-Zi Li

Yi Wang

Ming-Hui Zheng

Qiu-Shuang Xu

Li-Min Lei

Wen-Lu Ou-Yang

Ke-Xin Tang

Chang-Chun Li

Muhammad Hasnain Ehsan Ullah

Ling-Qing Yuan

Affiliations

Soon will be listed here.

Abstract

Vascular calcification is prevalent in aging, diabetes, chronic kidney disease, cardiovascular disease, and certain genetic disorders. However, the pathogenesis of vascular calcification is not well-understood. It has been progressively recognized that vascular calcification depends on the bidirectional interactions between vascular cells and their microenvironment. Exosomes are an essential bridge to mediate crosstalk between cells and organisms, and thus they have attracted increased research attention in recent years. Accumulating evidence has indicated that exosomes play an important role in cardiovascular disease, especially in vascular calcification. In this review, we introduce vascular biology and focus on the crosstalk between the different vessel layers and how their interplay controls the process of vascular calcification.

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