Resveratrol Attenuates High Glucose-Induced Osteoblast Dysfunction AKT/GSK3β/FYN-Mediated NRF2 Activation

Overview

Journal Front Pharmacol

Date 2022 Jun 9

PMID 35677434

Authors

Yue Xuan

Xiaohui Zhang

Jie Wang

Jiahao Li

Qingbo Liu

Guangping Lu

Mengjie Xiao

Ting Gao

Yuanfang Guo

Cong Cao

Ou Chen

Kunli Wang

Yufeng Tang

Junlian Gu

Affiliations

Soon will be listed here.

Abstract

Osteoblast dysfunction, induced by high glucose (HG), negatively impacts bone homeostasis and contributes to the pathology of diabetic osteoporosis (DOP). One of the most widely recognized mechanisms for osteoblast dysfunction is oxidative stress. Resveratrol (RES) is a bioactive antioxidant compound to combat oxidative damage. However, its role in the protection of HG-induced osteoblast dysfunction has not been clarified. Therefore, our study aimed to explore potential regulatory mechanisms of RES for attenuating HG-induced osteoblast dysfunction. Our results showed that osteoblast dysfunction under HG condition was significantly ameliorated by RES the activation of nuclear factor erythroid 2-related factor (NRF2) to suppress oxidative stress. Furthermore, using -shRNA and wortmannin, we identified that activation of NRF2 RES was regulated by the AKT/glycogen synthase kinase 3β (GSK3β)/FYN axis.

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