ERH Gene and Its Role in Cancer Cells

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Jun 9

PMID 35677162

Authors

Kun Pang

Mei-Li Li

Lin Hao

Zhen-Duo Shi

Harry Feng

Bo Chen

Yu-Yang Ma

Hao Xu

Deng Pan

Zhe-Sheng Chen

Cong-Hui Han

Affiliations

Soon will be listed here.

Abstract

Cancer is a major public health problem worldwide. Studies on oncogenes and tumor-targeted therapies have become an important part of cancer treatment development. In this review, we summarize and systematically introduce the gene enhancer of rudimentary homolog (ERH), which encodes a highly conserved small molecule protein. ERH mainly exists as a protein partner in human cells. It is involved in pyrimidine metabolism and protein complexes, acts as a transcriptional repressor, and participates in cell cycle regulation. Moreover, it is involved in DNA damage repair, mRNA splicing, the process of microRNA hairpins as well as erythroid differentiation. There are many related studies on the role of ERH in cancer cells; however, there are none on tumor-targeted therapeutic drugs or related therapies based on the expression of ERH. This study will provide possible directions for oncologists to further their research studies in this field.

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