Fatty Acids Composition and in Vivo Biochemical Effects of Aleurites Moluccana Seed (Candlenut) in Obese Wistar Rats

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2022 Jun 8

PMID 35676689

Authors

Matheus Camargos de Britto Rosa

Paula Reis Ribeiro

Viviam de Oliveira Silva

Danubia Aparecida de Carvalho Selvati-Rezende

Tacio Peres da Silva

Fernanda Rezende Souza

Maria das Gracas Cardoso

Josilene Nascimento Seixas

Eric Francelino Andrade

Vanessa Pardi

Ramiro Mendonca Murata

Luciano Jose Pereira

Affiliations

Soon will be listed here.

Abstract

Background: Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce.

Objective: To evaluate the effects of CN ingestion in obese rats.

Design: Thirty animals (obese and non-obese) received one of three different types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose-called 2CN. Treatment was maintained for 28 days.

Results: The fatty acid profile of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p < 0.05). A dose-dependent carcass fat reduction was observed (p < 0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p < 0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p > 0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononuclear leucocyte infiltrate.

Conclusions: Although CN presented beneficial effects on the metabolism of rats, it also caused increased risk of liver damage.

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