Ethnomedicinal Appraisal of Plants Used for the Treatment of Gastrointestinal Complaints by Tribal Communities Living in Diamir District, Western Himalayas, Pakistan

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2022 Jun 8

PMID 35675300

Authors

Rahmat Wali

Muhammad Faraz Khan

Ansar Mahmood

Majid Mahmood

Rahmatullah Qureshi

Khawaja Shafique Ahmad

Zia-Ur-Rehman Mashwani

Affiliations

Soon will be listed here.

Abstract

Majority of the mountain dwelling communities living in the Himalayas rely on traditional herbal medicines for primary healthcare needs. Present study was conducted in fairy meadows and allied valleys in District Diamir, Gilgit Baltistan autonomous territory in northern Pakistan. Documentation of traditional medicinal knowledge (TMK) of local communities for the treatment of gastrointestinal disorders was carried out as a component of a wider medico-botanical expedition conducted in the entire base camp of the great Nanga Parbat peak during 2016-19. Various ethnobotanical parameters i.e. use value (UV), informant consensus factor (ICF), Fidelity level (FL), direct matrix ranking test (DMRT) and preference ranking (PR) were applied to evaluate the data collected during field surveys. The plants were also subjected to a comparative review for novelty assessment. A total of 61 medicinal plant species belonging to 55 genera and 35 families are reported here for the treatment of GIDs. Compositae was the leading family with 8 (13%) species. Fourteen gastrointestinal disorders were cured with 32% taxon were reported for stomachic followed by diarrhea (15%) and constipation (14%). Highest use reports (5) and use citations (207) were reported for Mentha longifolia L. while highest UV (1.79) was obtained for Artemisia maritima L. Hylotelephium telephioides (Ledeb.), A. maritima, M. longifolia, M. piperita L., Allium cepa L., and A. annua L. exhibited 100% FL. Highest ICF was calculated against dysentery and flatulence. DMRT ranked Prunus persica L. first for its multipurpose uses. Taking constipation as a reference gastrointestinal disease, PR for ten plant species was calculated where H. telephioides was ranked first followed by A. maritima. Present study concluded that 19 out of 61 plant species were documented for the first time with novel medicinal uses to cure GIDs. These plant species could act as potential reservoirs of novel lead compounds for the treatments of gastrointestinal disorders.

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References

De Wet H, Nkwanyana M, Van Vuuren S . Medicinal plants used for the treatment of diarrhoea in northern Maputaland, KwaZulu-Natal Province, South Africa. J Ethnopharmacol. 2010; 130(2):284-9. DOI: 10.1016/j.jep.2010.05.004. View

An X, Bao Q, Di S, Zhao Y, Zhao S, Zhang H . The interaction between the gut Microbiota and herbal medicines. Biomed Pharmacother. 2019; 118:109252. DOI: 10.1016/j.biopha.2019.109252. View

Jabri M, Marzouki L, Sebai H . Ethnobotanical, phytochemical and therapeutic effects of Myrtus communis L. berries seeds on gastrointestinal tract diseases: a review. Arch Physiol Biochem. 2018; 124(5):390-396. DOI: 10.1080/13813455.2017.1423504. View

Zhang H, Ma Z . Phytochemical and Pharmacological Properties of Capparis spinosa as a Medicinal Plant. Nutrients. 2018; 10(2). PMC: 5852692. DOI: 10.3390/nu10020116. View

Paramanick D, Panday R, Shukla S, Sharma V . Primary Pharmacological and Other Important Findings on the Medicinal Plant "" (Aruna). J Pharmacopuncture. 2018; 20(2):89-92. PMC: 5532466. DOI: 10.3831/KPI.2017.20.011. View

Pawlowski S, Warren C, Guerrant R . Diagnosis and treatment of acute or persistent diarrhea. Gastroenterology. 2009; 136(6):1874-86. PMC: 2723735. DOI: 10.1053/j.gastro.2009.02.072. View

Bano A, Ahmad M, Hadda T, Saboor A, Sultana S, Zafar M . Quantitative ethnomedicinal study of plants used in the skardu valley at high altitude of Karakoram-Himalayan range, Pakistan. J Ethnobiol Ethnomed. 2014; 10:43. PMC: 4039317. DOI: 10.1186/1746-4269-10-43. View

Heinrich M, Ankli A, Frei B, Weimann C, Sticher O . Medicinal plants in Mexico: healers' consensus and cultural importance. Soc Sci Med. 1999; 47(11):1859-71. DOI: 10.1016/s0277-9536(98)00181-6. View

Ahmad S, Ullah F, Ayaz M, Sadiq A, Imran M . Antioxidant and anticholinesterase investigations of Rumex hastatus D. Don: potential effectiveness in oxidative stress and neurological disorders. Biol Res. 2015; 48:20. PMC: 4381421. DOI: 10.1186/s40659-015-0010-2. View

10.

Bellassoued K, Ben Hsouna A, Athmouni K, van Pelt J, Ayadi F, Rebai T . Protective effects of Mentha piperita L. leaf essential oil against CCl induced hepatic oxidative damage and renal failure in rats. Lipids Health Dis. 2018; 17(1):9. PMC: 5761127. DOI: 10.1186/s12944-017-0645-9. View

11.

Mishra A, Saklani S, Parcha V, Nigam M, Coutinho H . Antibacterial activity and phytochemical characterisation of Saussurea gossypiphora D. Don. Arch Microbiol. 2021; 203(8):5055-5065. DOI: 10.1007/s00203-021-02494-1. View

12.

Heinrich M, Rimpler H, Barrera N . Indigenous phytotherapy of gastrointestinal disorders in a lowland Mixe community (Oaxaca, Mexico): ethnopharmacologic evaluation. J Ethnopharmacol. 1992; 36(1):63-80. DOI: 10.1016/0378-8741(92)90062-v. View

13.

Iscan G, Kirimer N, Kurkcuoglu M, Baser K, Demirci F . Antimicrobial screening of Mentha piperita essential oils. J Agric Food Chem. 2002; 50(14):3943-6. DOI: 10.1021/jf011476k. View

14.

Rokaya M, Uprety Y, Poudel R, Timsina B, Munzbergova Z, Asselin H . Traditional uses of medicinal plants in gastrointestinal disorders in Nepal. J Ethnopharmacol. 2014; 158 Pt A:221-9. DOI: 10.1016/j.jep.2014.10.014. View

15.

Zougagh S, Belghiti A, Rochd T, Zerdani I, Mouslim J . Medicinal and Aromatic Plants Used in Traditional Treatment of the Oral Pathology: The Ethnobotanical Survey in the Economic Capital Casablanca, Morocco (North Africa). Nat Prod Bioprospect. 2018; 9(1):35-48. PMC: 6328421. DOI: 10.1007/s13659-018-0194-6. View

16.

Bano A, Ahmad M, Zafar M, Sultana S, Rashid S, Khan M . Ethnomedicinal knowledge of the most commonly used plants from Deosai Plateau, Western Himalayas, Gilgit Baltistan, Pakistan. J Ethnopharmacol. 2014; 155(2):1046-52. DOI: 10.1016/j.jep.2014.05.045. View

17.

Mukonowenzou N, Adeshina K, Donaldson J, Ibrahim K, Usman D, Erlwanger K . Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract. Front Physiol. 2021; 12:684464. PMC: 8363294. DOI: 10.3389/fphys.2021.684464. View

18.

Perez-Burillo S, Hinojosa-Nogueira D, Pastoriza S, Rufian-Henares J . Plant extracts as natural modulators of gut microbiota community structure and functionality. Heliyon. 2020; 6(11):e05474. PMC: 7677688. DOI: 10.1016/j.heliyon.2020.e05474. View

19.

Mahendran G, Rahman L . Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.)-A review. Phytother Res. 2020; 34(9):2088-2139. DOI: 10.1002/ptr.6664. View

20.

Qin Y, Jiao C, Huang S, Li Y, Zhang Z, Bao W . "Zuòyuèzi" dietary and behavioural associations with maternal health among puerperal women in South China. Asia Pac J Clin Nutr. 2021; 30(2):291-302. DOI: 10.6133/apjcn.202106_30(2).0014. View