» Articles » PMID: 35674043

Cardiovascular Events After Intracerebral Hemorrhage

Overview
Journal Stroke
Date 2022 Jun 8
PMID 35674043
Authors
Affiliations
Soon will be listed here.
Abstract

Cardiovascular events after primary intracerebral hemorrhage (ICH) have emerged as a leading cause of poor functional outcomes and mortality during the long-term recovery after an ICH. These events encompass arterial ischemic events such as ischemic stroke and myocardial infarction, arterial hemorrhagic events that include recurrent ICH, and venous thrombotic events such as venous thromboembolism. The purpose of this review is to summarize the cardiovascular complications after ICH, epidemiology and associated risk factors, and their impact on ICH outcomes. Additionally, we will highlight possible pathophysiological mechanisms to explain the short- and long-term increased risks of ischemic and hemorrhagic events after ICH. Finally, we will highlight potential secondary stroke and venous thrombotic prevention strategies often not considered after ICH, balanced against the risk of ICH recurrence.

Citing Articles

Antihypertensive Medication Class and Functional Outcomes After Nonlobar Intracerebral Hemorrhage.

Ridha M, Burke J, Sekar P, Woo D, Hannawi Y JAMA Netw Open. 2025; 8(2):e2457770.

PMID: 39899295 PMC: 11791703. DOI: 10.1001/jamanetworkopen.2024.57770.


Esketamine Provides Neuroprotection After Intracerebral Hemorrhage in Mice via the NTF3/PI3K/AKT Pathway.

Niu X, Zheng Y, Wang W, Zhang L, Wang S, Lu X CNS Neurosci Ther. 2024; 30(12):e70145.

PMID: 39690816 PMC: 11652676. DOI: 10.1111/cns.70145.


Acute Myocardial Injury in Spontaneous Intracerebral Hemorrhage: A Secondary Observational Analysis of the FAST Trial.

Rosso M, Stengl H, Scheitz J, Lewey J, Mayer S, Yaghi S J Am Heart Assoc. 2024; 13(17):e035053.

PMID: 39190583 PMC: 11646513. DOI: 10.1161/JAHA.124.035053.


Editorial: Targeting secondary brain damage following intracerebral hemorrhage: from bench to bedside, volume II.

Gao C Front Neurosci. 2024; 18:1413483.

PMID: 38756410 PMC: 11096588. DOI: 10.3389/fnins.2024.1413483.


Clinical features and associated factors of coexisting intracerebral hemorrhage in patients with cerebral small vessel disease: a cross-sectional study.

Gao Y, Zong C, Liu H, Zhang K, Yang H, Wang Y Sci Rep. 2024; 14(1):5596.

PMID: 38454101 PMC: 10920749. DOI: 10.1038/s41598-024-55968-9.


References
1.
Lerario M, Gialdini G, Lapidus D, Shaw M, Navi B, Merkler A . Risk of Ischemic Stroke after Intracranial Hemorrhage in Patients with Atrial Fibrillation. PLoS One. 2015; 10(12):e0145579. PMC: 4689346. DOI: 10.1371/journal.pone.0145579. View

2.
Kimberly W, Gilson A, Rost N, Rosand J, Viswanathan A, Smith E . Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy. Neurology. 2009; 72(14):1230-5. PMC: 2677484. DOI: 10.1212/01.wnl.0000345666.83318.03. View

3.
Xu T, Lin W, Feng Y, Shen F, Chen J, Wu W . Leukoaraiosis is associated with clinical symptom severity, poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage: a prospective multi-center cohort study. Neural Regen Res. 2021; 17(4):819-823. PMC: 8530112. DOI: 10.4103/1673-5374.322469. View

4.
Anderson C, Rodgers A, de Silva H, Martins S, Klijn C, Senanayake B . Triple Therapy Prevention of Recurrent Intracerebral Disease Events Trial: Rationale, design and progress. Int J Stroke. 2022; 17(10):1156-1162. DOI: 10.1177/17474930211068671. View

5.
Sprugel M, Kuramatsu J, Volbers B, Saam J, Sembill J, Gerner S . Impact of Statins on Hematoma, Edema, Seizures, Vascular Events, and Functional Recovery After Intracerebral Hemorrhage. Stroke. 2021; 52(3):975-984. DOI: 10.1161/STROKEAHA.120.029345. View