Recent Advances in Understanding the Role of HES6 in Cancers

Overview

Journal Theranostics

Date 2022 Jun 8

PMID 35673577

Authors

Imene Krossa

Thomas Strub

Arnaud Martel

Sacha Nahon-Esteve

Sandra Lassalle

Paul Hofman

Stephanie Baillif

Robert Ballotti

Corine Bertolotto

Affiliations

Soon will be listed here.

Abstract

The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers.

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