Zika Virus Infects Human Osteoclasts and Blocks Differentiation and Bone Resorption

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2022 Jun 7

PMID 35670284

Authors

Noreen Mumtaz

Marijke Koedam

Johannes P T M van Leeuwen

Marion P G Koopmans

Bram C J van der Eerden

Barry Rockx

Affiliations

Soon will be listed here.

Abstract

Bone-related complications are commonly reported following arbovirus infection. These arboviruses are known to disturb bone-remodeling and induce inflammatory bone loss via increased activity of bone resorbing osteoclasts (OCs). We previously showed that Zika virus (ZIKV) could disturb the function of bone forming osteoblasts, but the susceptibility of OCs to ZIKV infection is not known. Here, we investigated the effect of ZIKV infection on osteoclastogenesis and report that infection of pre- and early OCs with ZIKV significantly reduced the osteoclast formation and bone resorption. Interestingly, infection of pre-OCs with a low dose ZIKV infection in the presence of flavivirus cross-reacting antibodies recapitulated the phenotype observed with a high viral dose, suggesting a role for antibody-dependent enhancement in ZIKV-associated bone pathology. In conclusion, we have characterized a primary model to study the role of osteoclastogenesis in ZIKV pathogenesis, which will help to identify possible new targets for developing therapeutic and preventive measures.

Citing Articles

Offspring affected with Zika virus infection retain molecular footprints in the bone marrow and blood cells.

Udenze D, Trus I, Lipsit S, Napper S, Karniychuk U Emerg Microbes Infect. 2022; 12(1):2147021.

PMID: 36369716 PMC: 9869997. DOI: 10.1080/22221751.2022.2147021.

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