Zinc Improves Antibacterial, Anti-inflammatory and Cell Motility Activity of Chitosan for Wound Healing Applications

Overview

Journal Int J Biol Macromol

Publisher Elsevier

Date 2022 Jun 6

PMID 35667458

Authors

Nurshen Mutlu

Liliana Liverani

Fatih Kurtuldu

Dusan Galusek

Aldo R Boccaccini

Affiliations

Soon will be listed here.

Abstract

We report the successful preparation and characterization of chitosan-Zn complex (ChiZn) in the form of films, intended to enhance the biological performance of chitosan by the presence of Zn as antibacterial agent and biologically active ion. The influence of Zn chelation on morphology and structure of chitosan was assessed by scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and infrared spectroscopy. The biodegradability study of ChiZn showed a sustained release of Zn up to 2 mg/mL. No toxic response was observed toward stromal cell line ST-2 in indirect contact with the ChiZn films. The dissolution product of ChiZn showed improved wound closure (88% closure) compared to the positive control group (70% closure). Moreover, ChiZn exhibited antibacterial activity against S. aureus together with a slight increase (~30%) in the secretion of VEGF and moderate decrease in nitric oxide evolution. Our findings indicate that ChiZn could be used as a safe and effective wound healing agent.

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