» Articles » PMID: 35665122

COVID-19 and Liver Diseases, What We Know So Far

Overview
Specialty General Medicine
Date 2022 Jun 6
PMID 35665122
Authors
Affiliations
Soon will be listed here.
Abstract

Coronavirus disease 2019 (COVID-19) pneumonia outbreak started in December 2019. On March 12, 2020, the World Health Organization (WHO) declared that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a pandemic, and as of May 2021, SARS-CoV-2 has infected over 167.3 million patients, including 3.4 million deaths, reported to WHO. In this review, we will focus on the relationship between SARS-CoV-2 infection and the liver. We will discuss how chronic liver diseases affect the COVID-19 disease course and outcomes. We will also discuss the SARS-CoV-2 effects on the liver, mechanisms of acute liver injury, and potential management plans.

Citing Articles

New Insights into the Effects of SARS-CoV-2 on Metabolic Organs: A Narrative Review of COVID-19 Induced Diabetes.

Li L, Li L, Cai X, Pan Z Diabetes Metab Syndr Obes. 2024; 17:1383-1389.

PMID: 38529167 PMC: 10962470. DOI: 10.2147/DMSO.S454408.


Altered Liver Biochemistry and Mortality in Patients Hospitalized With COVID-19.

Munoz Rossi F, Gallo Orjuela D, Guaiquil A, Gonzalez C, Salazar Agudelo J, Quinapanta Castro N Cureus. 2024; 16(2):e54218.

PMID: 38496100 PMC: 10943261. DOI: 10.7759/cureus.54218.


An Updated Systematic Review and Meta-Analysis of the Association between the De Ritis Ratio and Disease Severity and Mortality in Patients with COVID-19.

Mangoni A, Zinellu A Life (Basel). 2023; 13(6).

PMID: 37374107 PMC: 10303964. DOI: 10.3390/life13061324.


Effect of SARS-CoV-2 infection on the liver.

Sanyaolu A, Marinkovic A, Abbasi A, Prakash S, Patidar R, Desai P World J Virol. 2023; 12(2):109-121.

PMID: 37033147 PMC: 10075054. DOI: 10.5501/wjv.v12.i2.109.


COVID-19 and liver injury: An ongoing challenge.

Papagiouvanni I, Kotoulas S, Pataka A, Spyratos D, Porpodis K, Boutou A World J Gastroenterol. 2023; 29(2):257-271.

PMID: 36687117 PMC: 9846934. DOI: 10.3748/wjg.v29.i2.257.


References
1.
Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G . A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020; 382(19):1787-1799. PMC: 7121492. DOI: 10.1056/NEJMoa2001282. View

2.
Tapper E, Robson S, Malik R . Coagulopathy in cirrhosis - the role of the platelet in hemostasis. J Hepatol. 2013; 59(4):889-90. DOI: 10.1016/j.jhep.2013.03.040. View

3.
Liang W, Guan W, Chen R, Wang W, Li J, Xu K . Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020; 21(3):335-337. PMC: 7159000. DOI: 10.1016/S1470-2045(20)30096-6. View

4.
Arvaniti V, DAmico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M . Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010; 139(4):1246-56, 1256.e1-5. DOI: 10.1053/j.gastro.2010.06.019. View

5.
Qian Q, Fan L, Liu W, Li J, Yue J, Wang M . Direct Evidence of Active SARS-CoV-2 Replication in the Intestine. Clin Infect Dis. 2020; 73(3):361-366. PMC: 7454471. DOI: 10.1093/cid/ciaa925. View