Multiple Isolated Ovarian Cancer Recurrences in the Cervix and Vagina After Supracervical Hysterectomy: A Case Report

Overview

Journal Gynecol Oncol Rep

Publisher Elsevier

Date 2022 Jun 6

PMID 35663846

Authors

Anh Q Nguyen

Sarah Ehmann

Jaqueline Feinberg

William P Tew

Karen Carthew

Yuko Sonoda

Dennis S Chi

Affiliations

Soon will be listed here.

Abstract

We present a rare case of a patient who was treated for advanced-stage ovarian cancer with optimal debulking surgery that included a supracervical hysterectomy, instead of total abdominal hysterectomy, who subsequently developed 3 isolated recurrences in the cervix and vagina. We suggest there may be a link between the type of hysterectomy and location of recurrence; we also emphasize the importance of pelvic exam and Papanicolaou smear for patients who have undergone supracervical hysterectomy as part of their ovarian cancer debulking surgery.

References

Milam M, Sood A, King S, Bassett Jr R, Lu K, Slomovitz B . Supracervical hysterectomy in patients with advanced epithelial ovarian cancer. Obstet Gynecol. 2007; 109(3):641-6. DOI: 10.1097/01.AOG.0000257117.78230.0f. View

Siegel R, Miller K, Fuchs H, Jemal A . Cancer statistics, 2022. CA Cancer J Clin. 2022; 72(1):7-33. DOI: 10.3322/caac.21708. View

Winter 3rd W, Maxwell G, Tian C, Carlson J, Ozols R, Rose P . Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol. 2007; 25(24):3621-7. DOI: 10.1200/JCO.2006.10.2517. View

Feinberg J, Carthew K, Webster E, Chang K, McNeil N, Chi D . Ovarian cancer recurrence detection may not require in-person physical examination: an MSK team ovary study. Int J Gynecol Cancer. 2021; 32(2):159-164. PMC: 8825707. DOI: 10.1136/ijgc-2021-002885. View

Markman M, Walker J . Intraperitoneal chemotherapy of ovarian cancer: a review, with a focus on practical aspects of treatment. J Clin Oncol. 2006; 24(6):988-94. DOI: 10.1200/JCO.2005.05.2456. View

Fanning J, Kesterson J, Benton A, Farag S, Dodson-Ludlow K . Laparoscopy-assisted supracervical hysterectomy for ovarian cancer: cervical recurrence. JSLS. 2014; 18(3). PMC: 4154411. DOI: 10.4293/JSLS.2014.00232. View

Winter 3rd W, Maxwell G, Tian C, Sundborg M, Rose G, Rose P . Tumor residual after surgical cytoreduction in prediction of clinical outcome in stage IV epithelial ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol. 2007; 26(1):83-9. DOI: 10.1200/JCO.2007.13.1953. View

Vaccarello L, Rubin S, Vlamis V, Wong G, Jones W, Lewis J . Cytoreductive surgery in ovarian carcinoma patients with a documented previously complete surgical response. Gynecol Oncol. 1995; 57(1):61-5. DOI: 10.1006/gyno.1995.1099. View

Green A, Feinberg J, Makker V . A Review of Immune Checkpoint Blockade Therapy in Endometrial Cancer. Am Soc Clin Oncol Educ Book. 2020; 40:1-7. DOI: 10.1200/EDBK_280503. View

10.

Cannistra S . Cancer of the ovary. N Engl J Med. 2004; 351(24):2519-29. DOI: 10.1056/NEJMra041842. View

11.

Firat S, Erickson B . Selective irradiation for the treatment of recurrent ovarian carcinoma involving the vagina or rectum. Gynecol Oncol. 2001; 80(2):213-20. DOI: 10.1006/gyno.2000.6059. View

12.

Amate P, Huchon C, Dessapt A, Bensaid C, Medioni J, LE Frere Belda M . Ovarian cancer: sites of recurrence. Int J Gynecol Cancer. 2013; 23(9):1590-6. DOI: 10.1097/IGC.0000000000000007. View

13.

Hoskins W, McGuire W, Brady M, Homesley H, Creasman W, Berman M . The effect of diameter of largest residual disease on survival after primary cytoreductive surgery in patients with suboptimal residual epithelial ovarian carcinoma. Am J Obstet Gynecol. 1994; 170(4):974-9; discussion 979-80. DOI: 10.1016/s0002-9378(94)70090-7. View

14.

Ushijima K . Treatment for recurrent ovarian cancer-at first relapse. J Oncol. 2010; 2010:497429. PMC: 2801501. DOI: 10.1155/2010/497429. View

15.

Gershenson D, Copeland L, Wharton J, Atkinson E, Sneige N, Edwards C . Prognosis of surgically determined complete responders in advanced ovarian cancer. Cancer. 1985; 55(5):1129-35. DOI: 10.1002/1097-0142(19850301)55:5<1129::aid-cncr2820550531>3.0.co;2-o. View